ArticleChest2011
Determinants of exhaled breath condensate pH in a large population with asthma.
Article in Chest, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 69 citations in OpenAlex.
- Exhaled breath condensate pH does not discriminate asymptomatic gastroesophageal reflux or the response to lansoprazole treatment in children with poorly controlled asthma.The journal of allergy and clinical immunology. In practiceTrial
- Asthma Phenotypes and Biomarkers.Respiratory care · 2025Review
- Inflammation-induced loss of CFTR-expressing airway ionocytes in non-eosinophilic asthma.Respirology (Carlton, Vic.) · 2025Article
- The Role of Exhaled Breath Condensate in Chronic Inflammatory and Neoplastic Diseases of the Respiratory Tract.International journal of molecular sciences · 2024Review
- Diet Quality and Exhaled Breath Condensate Markers in a Sample of School-Aged Children.Children (Basel, Switzerland) · 2023Article
- Neutrophils and Asthma.Diagnostics (Basel, Switzerland) · 2022Review
- Optical biosensing of markers of mucosal inflammation.Nanomedicine : nanotechnology, biology, and medicine · 2022Article
- Recent insights in the role of biomarkers in severe asthma management.Frontiers in medicine · 2022Review
- Evaluation of respiratory function and biomarkers of exposure to mixtures of pollutants in brick-kilns workers from a marginalized urban area in Mexico.Environmental science and pollution research international · 2021Article
- Pruning of the Pulmonary Vasculature in Asthma. The Severe Asthma Research Program (SARP) Cohort.American journal of respiratory and critical care medicine · 2018Article
- Article
- Biomarkers and severe asthma: a critical appraisal.Clinical and molecular allergy : CMA · 2015Review
- Exhaled Breath Condensate: Technical and Diagnostic Aspects.TheScientificWorldJournal · 2015Review
- Asthma across the ages: knowledge gaps in childhood asthma.The Journal of allergy and clinical immunology · 2014Review
- An association between L-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype.American journal of respiratory and critical care medicine · 2013Article
- Biomarkers for gastroesophageal reflux in respiratory diseases.Gastroenterology research and practice · 2013Article
- Biomarkers in asthma: a real hope to better manage asthma.Clinics in chest medicine · 2012Review
- The GPCR OGR1 (GPR68) mediates diverse signalling and contraction of airway smooth muscle in response to small reductions in extracellular pH.British journal of pharmacology · 2012Article
- Exhaled breath condensates: analyzing the expiratory plume.American journal of respiratory and critical care medicine · 2012Article
- Residential proximity to a major roadway is associated with features of asthma control in children.PloS one · 2012Article
Corrections and comments
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Authors and funding
21 authors at 11 institutions in 2 countries.
Funding
Abstract
backgroundExhaled breath condensate (EBC) pH is 2 log orders below normal during acute asthma exacerbations and returns to normal with antiinflammatory therapy. However, the determinants of EBC pH, particularly in stable asthma, are poorly understood. We hypothesized that patients with severe asthma would have low EBC pH and that there would be an asthma subpopulation of patients with characteristically low values.
methodsWe studied the association of EBC pH with clinical characteristics in 572 stable subjects enrolled in the Severe Asthma Research Program. These included 250 subjects with severe asthma, 291 with nonsevere asthma, and 31 healthy control subjects.
resultsOverall, EBC in this population of stable, treated study subjects was not lower in severe asthma (8.02; interquartile range [IQR], 7.61-8.41) or nonsevere asthma (7.90; IQR, 7.52-8.20) than in control subjects (7.9; IQR, 7.40-8.20). However, in subjects with asthma the data clustered below and above pH 6.5. Subjects in the subpopulation with pH < 6.5 had lower fraction of exhaled NO (FeNO) values (FeNO = 22.6 ± 18.1 parts per billion) than those with pH ≥ 6.5 (39.9 ± 40.2 parts per billion; P < .0001). By multiple linear regression, low EBC pH was associated with high BMI, high BAL neutrophil counts, low prebronchodilator FEV(1) ratio, high allergy symptoms, race other than white, and gastroesophageal reflux symptoms.
conclusionAsthma is a complex syndrome. Subjects who are not experiencing an exacerbation but have low EBC pH appear to be a unique subpopulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.