ArticleEnvironmental health perspectives2011
Home characteristics as predictors of bacterial and fungal microbial biomarkers in house dust.
Article in Environmental health perspectives, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of indoor microbial aerosols with respiratory symptoms among under-five children: a systematic review and meta-analysis.Environmental health : a global access science source · 2021Pooled it
- Trial
- Fungal diversity in homes and asthma morbidity among school-age children in New York City.Environmental research · 2023Article
- Indoor Airborne Microbiome and Endotoxin: Meteorological Events and Occupant Characteristics Are Important Determinants.Environmental science & technology · 2023Article
- Impacts of heat stress on immune responses and oxidative stress in farm animals and nutritional strategies for amelioration.International journal of biometeorology · 2021Review
- Opportunities for evaluating chemical exposures and child health in the United States: the Environmental influences on Child Health Outcomes (ECHO) Program.Journal of exposure science & environmental epidemiology · 2020Review
- Bacterial community analysis of floor dust and HEPA filters in air purifiers used in office rooms in ILAS, Beijing.Scientific reports · 2020Article
- Indoor Microbiome: Quantification of Exposure and Association with Geographical Location, Meteorological Factors, and Land Use in France.Microorganisms · 2020Article
- Quantitative assessment of microbes from samples of indoor air and dust.Journal of exposure science & environmental epidemiology · 2018Article
- Indoor microbiota in severely moisture damaged homes and the impact of interventions.Microbiome · 2017Article
- NIAID, NIEHS, NHLBI, and MCAN Workshop Report: The indoor environment and childhood asthma-implications for home environmental intervention in asthma prevention and management.The Journal of allergy and clinical immunology · 2017Article
- Reducing indoor air pollutants with air filtration units in wood stove homes.The Science of the total environment · 2017Article
- House Dust Endotoxin and Peripheral Leukocyte Counts: Results from Two Large Epidemiologic Studies.Environmental health perspectives · 2017Article
- Pediatric Asthma and the Indoor Microbial Environment.Current environmental health reports · 2016Review
- Allergies and Asthma: Do Atopic Disorders Result from Inadequate Immune Homeostasis arising from Infant Gut Dysbiosis?Expert review of clinical immunology · 2016Article
- Predictors of microbial agents in dust and respiratory health in the Ecrhs.BMC pulmonary medicine · 2015Article
- Asthma and allergy development: contrasting influences of yeasts and other fungal exposures.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2015Article
- Environmental remediation in the treatment of allergy and asthma: latest updates.Current allergy and asthma reports · 2014Review
- Indoor water and dampness and the health effects on children: a review.Current allergy and asthma reports · 2013Review
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundMeasurement of fungal and bacterial biomarkers can be costly, but it is not clear whether home characteristics can be used as a proxy of these markers, particularly if the purpose is to differentiate specific classes of biologic exposures that have similar sources but may have different effects on allergic disease risk.
objectiveWe evaluated home characteristics as predictors of multiple microbial biomarkers, with a focus on common and unique determinants and with attention to the extent of their explanatory ability.
methodsIn 376 Boston-area homes enrolled in a cohort study of home exposures and childhood asthma, we assessed the relationship between home characteristics gathered by questionnaire and measured gram-negative bacteria (GNB) (endotoxin and C10:0, C12:0, and C14:0 3-hydroxy fatty acids), gram-positive bacteria (GPB) (N-acetyl muramic acid), and fungal biomarkers [ergosterol and (1→6) branched, (1→3) β-D glucans] in bed and family room dust.
resultsHome characteristics related to dampness were significant predictors of all microbial exposures; water damage or visible mold/mildew in the home was associated with a 20-66% increase in GNB levels. Report of cleaning the bedroom at least once a week was associated with reduced GNB, GPB, and fungi. Presence of dogs or cats predicted increases in home bacteria or fungi. The proportion of variance in microbial biomarkers explained by home characteristics ranged from 4.2% to 19.0%.
conclusionsDespite their associations with multiple microbial flora, home characteristics only partially explain the variability in microbial biomarker levels and cannot substitute for specific microbial measurements in studies concerned with distinguishing effects of specific classes of microbes.
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