ArticleBiomaterials2010
Gadonanotubes as magnetic nanolabels for stem cell detection.
Article in Biomaterials, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Applications of Filled Single-Walled Carbon Nanotubes: Progress, Challenges, and Perspectives.Nanomaterials (Basel, Switzerland) · 2021Review
- Nanotechnology in cardiac stem cell therapy: cell modulation, imaging and gene delivery.RSC advances · 2021Review
- Review on Recent Progress in Magnetic Nanoparticles: Synthesis, Characterization, and Diverse Applications.Frontiers in chemistry · 2021Review
- Gadolinium-containing carbon nanomaterials for magnetic resonance imaging: Trends and challenges.Journal of cellular and molecular medicine · 2020Review
- Labeling Stem Cells with a New Hybrid Bismuth/Carbon Nanotube Contrast Agent for X-Ray Imaging.Contrast media & molecular imaging · 2019Article
- A promising magnetic resonance stem cell tracer based on natural biomaterials in a biological system: manganese(II) chelated to melanin nanoparticles.International journal of nanomedicine · 2018Article
- A New High-Performance Gadonanotube-Polymer Hybrid Material for Stem Cell Labeling and Tracking by MRI.Contrast media & molecular imaging · 2018Article
- Carbon nanotube capsules enhance the in vivo efficacy of cisplatin.Acta biomaterialia · 2017Article
- Nanoparticles-Assisted Stem Cell Therapy for Ischemic Heart Disease.Stem cells international · 2016Review
- A novel redox-sensitive system based on single-walled carbon nanotubes for chemo-photothermal therapy and magnetic resonance imaging.International journal of nanomedicine · 2016Article
- Stable confinement of positron emission tomography and magnetic resonance agents within carbon nanotubes for bimodal imaging.Nanomedicine (London, England) · 2014Article
- The use of gadolinium-carbon nanostructures to magnetically enhance stem cell retention for cellular cardiomyoplasty.Biomaterials · 2014Article
- Dialytic Separation of Bundled, Functionalized Carbon Nanotubes from Carbonaceous Impurities.Crystals · 2014Article
- Cytotoxicity, cytocompatibility, cell-labeling efficiency, and in vitro cellular magnetic resonance imaging of gadolinium-catalyzed single-walled carbon nanotubes.Journal of biomedical materials research. Part A · 2013Article
- Bismuth@US-tubes as a Potential Contrast Agent for X-ray Imaging Applications.Journal of materials chemistry. B · 2013Article
- Toward single-walled carbon nanotube-gadolinium complex as advanced MRI contrast agents: pharmacodynamics and global genomic response in small animals.Journal of biomedical materials research. Part B, Applied biomaterials · 2013Article
- MRI tracking of macrophages labeled with glucan particles entrapping a water insoluble paramagnetic Gd-based agent.Molecular imaging and biology · 2013Article
- Superparamagnetic iron oxide nanoparticles as MRI contrast agents for non-invasive stem cell labeling and tracking.Theranostics · 2013Review
- Gadolinium(3+)-doped mesoporous silica nanoparticles as a potential magnetic resonance tracer for monitoring the migration of stem cells in vivo.International journal of nanomedicine · 2013Article
- Labeling human mesenchymal stem cells with gold nanocages for in vitro and in vivo tracking by two-photon microscopy and photoacoustic microscopy.Theranostics · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Stem cell-based therapies have emerged as a promising approach in regenerative medicine. In the development of such therapies, the demand for imaging technologies that permit the noninvasive monitoring of transplanted stem cells in vivo is growing. Here, we report the performance of gadolinium-containing carbon nanocapsules, or gadonanotubes (GNTs), as a new T₁-weighted magnetic resonance imaging (MRI) intracellular labeling agent for pig bone marrow-derived mesenchymal stem cells (MSCs). Without the use of a transfection agent, micromolar concentrations of GNTs can deliver up to 10⁹ Gd(3+) ions per cell without compromising cell viability, differentiation potential, proliferation pattern, and phenotype. Imaging 10 × 10⁶ GNT-labeled MSCs demonstrates a nearly two-fold reduction in T₁ relaxation time when compared to unlabeled MSCs at 1.5 T in a clinical MRI scanner, which easily permits the discrimination of GNT-labeled MSCs in a T₁-weighted MR image. It is anticipated that GNTs will allow in vivo tracking of GNT-labeled MSCs, as well as other mammalian cell types, by T₁-weighted imaging with greater efficacy than other current technologies now allow.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.