ReviewPharmacology & therapeutics2011
Targeting stem cell niches and trafficking for cardiovascular therapy.
Review in Pharmacology & therapeutics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Endogenous Mobilization of Mesenchymal Stromal Cells: A Pathway for Interorgan Communication?Frontiers in cell and developmental biology · 2020Review
- Exosomes from conditioned media of bone marrow-derived mesenchymal stem cells promote bone regeneration by enhancing angiogenesis.PloS one · 2019Article
- Transforming growth factor-β in stem cells and tissue homeostasis.Bone research · 2018Article
- Strategies to develop endogenous stem cell-recruiting bioactive materials for tissue repair and regeneration.Advanced drug delivery reviews · 2017Review
- Migration of bone marrow progenitor cells in the adult brain of rats and rabbits.World journal of stem cells · 2016Review
- PDL regeneration via cell homing in delayed replantation of avulsed teeth.Journal of translational medicine · 2015Article
- Avemar and Echinacea extracts enhance mobilization and homing of CD34(+) stem cells in rats with acute myocardial infarction.Stem cell research & therapy · 2015Article
- Suicide gene-mediated sequencing ablation revealed the potential therapeutic mechanism of induced pluripotent stem cell-derived cardiovascular cell patch post-myocardial infarction.Antioxidants & redox signaling · 2014Article
- Mesenchymal stem cells recruited by active TGFβ contribute to osteogenic vascular calcification.Stem cells and development · 2014Article
- Differentiation induction of mouse cardiac stem cells into sinus node-like cells by co-culturing with sinus node.International journal of clinical and experimental pathology · 2014Article
- Regulatory systems in bone marrow for hematopoietic stem/progenitor cells mobilization and homing.BioMed research international · 2013Review
- Redox regulation of stem/progenitor cells and bone marrow niche.Free radical biology & medicine · 2013Review
- Cardiac stem cell niche, MMP9, and culture and differentiation of embryonic stem cells.Methods in molecular biology (Clifton, N.J.) · 2013Article
- Injury-activated transforming growth factor β controls mobilization of mesenchymal stem cells for tissue remodeling.Stem cells (Dayton, Ohio) · 2012Article
- NADPH oxidase 2 regulates bone marrow microenvironment following hindlimb ischemia: role in reparative mobilization of progenitor cells.Stem cells (Dayton, Ohio) · 2012Article
- Stem cells in thoracic aortic aneurysms and dissections: potential contributors to aortic repair.The Annals of thoracic surgery · 2012Article
- Challenges for heart disease stem cell therapy.Vascular health and risk management · 2012Review
- Remote ischemic conditioning: from bench to bedside.Frontiers in physiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
Regenerative cardiovascular medicine is the frontline of 21st-century health care. Cell therapy trials using bone marrow progenitor cells documented that the approach is feasible, safe and potentially beneficial in patients with ischemic disease. However, cardiovascular prevention and rehabilitation strategies should aim to conserve the pristine healing capacity of a healthy organism as well as reactivate it under disease conditions. This requires an increased understanding of stem cell microenvironment and trafficking mechanisms. Engagement and disengagement of stem cells of the osteoblastic niche is a dynamic process, finely tuned to allow low amounts of cells move out of the bone marrow and into the circulation on a regular basis. The balance is altered under stress situations, like tissue injury or ischemia, leading to remarkably increased cell egression. Individual populations of circulating progenitor cells could give rise to mature tissue cells (e.g. endothelial cells or cardiomyocytes), while the majority may differentiate to leukocytes, affecting the environment of homing sites in a paracrine way, e.g. promoting endothelial survival, proliferation and function, as well as attenuating or enhancing inflammation. This review focuses on the dynamics of the stem cell niche in healthy and disease conditions and on therapeutic means to direct stem cell/progenitor cell mobilization and recruitment into improved tissue repair.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.