ReviewFEBS letters2010
Signaling microdomains in T cells.
Review in FEBS letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 56 citations in OpenAlex.
- Impairment of non-muscle myosin IIA in human CD4+ T cells contributes to functional deficits in the elderly.Cellular & molecular immunology · 2012Trial
- Molecular Dynamics Simulations of Immune Receptors and Ligands.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Stochastic model of T cell repolarization during target elimination (II).Biophysical journal · 2022Article
- Insights into intercellular receptor-ligand binding kinetics in cell communication.Frontiers in bioengineering and biotechnology · 2022Review
- PLCγ1 promotes phase separation of T cell signaling components.The Journal of cell biology · 2021Article
- Cooperative Stabilization of Close-Contact Zones Leads to Sensitivity and Selectivity in T-Cell Recognition.Cells · 2021Article
- Wiskott-Aldrich Syndrome Protein: Roles in Signal Transduction in T Cells.Frontiers in cell and developmental biology · 2021Review
- Expamers: a new technology to control T cell activation.Scientific reports · 2020Article
- Stochastic Model of T Cell Repolarization during Target Elimination I.Biophysical journal · 2020Article
- Orchestration of Immunological Synapse Assembly by Vesicular Trafficking.Frontiers in cell and developmental biology · 2019Review
- Galectin-9 binds IgM-BCR to regulate B cell signaling.Nature communications · 2018Article
- Article
- Peptide-MHC-based nanomedicines for autoimmunity function as T-cell receptor microclustering devices.Nature nanotechnology · 2017Article
- Controlling T-Cell Activation with Synthetic Dendritic Cells Using the Multivalency Effect.ACS omega · 2017Article
- Nanoscale Relationship Between CD4 and CD25 of T Cells Visualized with NSOM/QD-Based Dual-Color Imaging System.Nanoscale research letters · 2015Article
- Behavior and Properties of Mature Lytic Granules at the Immunological Synapse of Human Cytotoxic T Lymphocytes.PloS one · 2015Article
- Current approaches to studying membrane organization.F1000Research · 2015Review
- Receptor Pre-Clustering and T cell Responses: Insights into Molecular Mechanisms.Frontiers in immunology · 2014Review
- Centrosome repositioning in T cells is biphasic and driven by microtubule end-on capture-shrinkage.The Journal of cell biology · 2013Article
- Signaling from the podocyte intercellular junction to the actin cytoskeleton.Seminars in nephrology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Sub-micron scale signaling domains induced in the plasma membrane of cells are thought to play important roles in signal transduction. In T cells, agonist MHC-peptide complexes induce small diffraction-limited domains enriched in T cell receptor (TCR) and signaling molecules. These microclusters serve as transient platforms for signal initiation and are required for sustained signaling in T cells, although each microcluster functions for only a couple of minutes. How they are formed, and what mechanisms promote and regulate signaling within TCR microclusters is largely unknown, although it is clear that TCR engagement and dynamic reorganization of cortical actin are involved. Here, we review current understanding of signaling within microclusters in T cells, and speculate on how these structures may form, initiate biochemical signals, and serve as sites of both signal integration and amplification, while also facilitating appropriate termination of TCR and related signaling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.