Evidence map›Paper›PMID 20965144›Full record

ReviewArchives of biochemistry and biophysics2011

Troponin T isoforms and posttranscriptional modifications: Evolution, regulation and function.

Bin Wei, J-P Jin

Abstract readReview
In one paragraph

Review in Archives of biochemistry and biophysics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 143 citations in OpenAlex.

  1. Review
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  10. Photodynamic Therapy for Atherosclerosis.International journal of molecular sciences · 2024
    Review
  11. Review
  12. Article
  13. High sensitivity top-down proteomics captures single muscle cell heterogeneity in large proteoforms.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  14. Article
  15. Article
  16. Review
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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Bin WeiDepartment of Physiology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
J-P Jin
Wayne State University · US

Funding

Role of Troponin T Isoforms in Nemaline MyopathyR01AR048816 · NIAMS · WAYNE STATE UNIVERSITY · PI JIN, JIAN-PING · 2003 to 2014
$3.2M
Proteolytic Regulation of Troponin T & Cardiac FunctionR01HL098945 · NHLBI · WAYNE STATE UNIVERSITY · PI JIN, JIAN-PING · 2010 to 2014
$2.0M
Troponin structure &function in cardiomyopathyR01HL078773 · NHLBI · WAYNE STATE UNIVERSITY · PI JIN, JIAN-PING · 2005 to 2008
$1.3M
NHLBI NIH HHS HL078773NHLBI NIH HHS HL098945NHLBI NIH HHS R01 HL078773NHLBI NIH HHS R01 HL098945NIAMS NIH HHS AR048816NIAMS NIH HHS R01 AR048816
6 · The paper itself

Abstract

Troponin-mediated Ca²(+)-regulation governs the actin-activated myosin motor function which powers striated (skeletal and cardiac) muscle contraction. This review focuses on the structure-function relationship of troponin T, one of the three protein subunits of the troponin complex. Molecular evolution, gene regulation, alternative RNA splicing, and posttranslational modifications of troponin T isoforms in skeletal and cardiac muscles are summarized with emphases on recent research progresses. The physiological and pathophysiological significances of the structural diversity and regulation of troponin T are discussed for impacts on striated muscle function and adaptation in health and diseases.

Indexed as

Evolution, MolecularProtein Processing, Post-TranslationalAnimalsHumansProtein IsoformsProtein Structure, TertiarySpecies SpecificityTroponin TProtein IsoformsTroponin T

Identifiers

PMID20965144
PMCPMC3018564
OpenAlexW2095468262

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.