ArticleBMC plant biology2010
Functional annotation, genome organization and phylogeny of the grapevine (Vitis vinifera) terpene synthase gene family based on genome assembly, FLcDNA cloning, and enzyme assays.
Article in BMC plant biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 209 papers, 1 of them a synthesis that pooled it.
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Who cites it
209 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Grape Berry Secondary Metabolites and Their Modulation by Abiotic Factors in a Climate Change Scenario-A Review.Frontiers in plant science · 2021Pooled it
- Review
- Integrated omics identifies VviGTs and VviMYB174 as drivers of glycosylated monoterpenoid accumulation in 'Ruiduhongyu' grapes.Horticulture research · 2026Article
- Genomic mechanism of aroma terpenoids biosynthesis in plants.Journal of advanced research · 2026Review
- Biosynthesis and heterologous production of the α-agarofuran scaffold of Celangulin V from Celastrus angulatus.Nature communications · 2026Article
- Molecular evolution of terpene synthase underlying the diversification of isoprene emission in Fagaceae.Plant biology (Stuttgart, Germany) · 2026Article
- Genome-wide discovery and characterization of terpene synthases contributing to strawberry aroma metabolism.Plant physiology · 2026Article
- Evolutionary and molecular insights into the terpene synthase gene (TPS) family in the medicinal plant Bidens alba.Scientific reports · 2026Article
- Pan-genomic analysis and abiotic stress expression of eight TPS gene families in Brassica napus.BMC plant biology · 2026Article
- Variation in Fruit Quality and Aroma Biosynthesis of 'Summer Black' Grape in Southern China.Genes · 2026Article
- Identification and Analysis of the Terpene Synthases (TPS) Gene Family in Camellia Based on Pan-Genome.Genes · 2026Article
- Transcriptional Modulation in Grapevine by a Biostimulant Treatment for Improved Plant Resilience to Stress Events.Plants (Basel, Switzerland) · 2026Article
- A multivariate Bayesian modeling strategy coupled with QTL analysis reveals genetic loci linking important sensory wine quality attributes with their corresponding wine aroma compounds.Frontiers in plant science · 2026Article
- Tracing the Evolutionary Dynamics and the Transcriptional Partitioning of Terpene Synthase Gene Family inBioinformatics and biology insights · 2026Article
- Genome-wide analysis and functional characterization ofFrontiers in plant science · 2026Article
- A chromosome-level genome of Astilbe chinensis unveils the evolution of a terpene biosynthetic gene cluster.Nature communications · 2025Article
- Systematic identification of terpene synthases from sacred lotus (Horticulture research · 2025Article
- Genome-Wide Analysis of Terpene Synthase Genes inInternational journal of molecular sciences · 2025Article
- GWAS identifies a molecular marker cluster associated with monoterpenoids in grapes.Horticulture research · 2025Article
- Genomic analysis of terpene synthase family and characterization of ent-kaurene synthase in Chenopodium quinoa.Molecular genetics and genomics : MGG · 2025Article
149 more citing papers are in PubMed but not listed here.
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8 authors.
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Abstract
backgroundTerpenoids are among the most important constituents of grape flavour and wine bouquet, and serve as useful metabolite markers in viticulture and enology. Based on the initial 8-fold sequencing of a nearly homozygous Pinot noir inbred line, 89 putative terpenoid synthase genes (VvTPS) were predicted by in silico analysis of the grapevine (Vitis vinifera) genome assembly 1. The finding of this very large VvTPS family, combined with the importance of terpenoid metabolism for the organoleptic properties of grapevine berries and finished wines, prompted a detailed examination of this gene family at the genomic level as well as an investigation into VvTPS biochemical functions.
resultsWe present findings from the analysis of the up-dated 12-fold sequencing and assembly of the grapevine genome that place the number of predicted VvTPS genes at 69 putatively functional VvTPS, 20 partial VvTPS, and 63 VvTPS probable pseudogenes. Gene discovery and annotation included information about gene architecture and chromosomal location. A dense cluster of 45 VvTPS is localized on chromosome 18. Extensive FLcDNA cloning, gene synthesis, and protein expression enabled functional characterization of 39 VvTPS; this is the largest number of functionally characterized TPS for any species reported to date. Of these enzymes, 23 have unique functions and/or phylogenetic locations within the plant TPS gene family. Phylogenetic analyses of the TPS gene family showed that while most VvTPS form species-specific gene clusters, there are several examples of gene orthology with TPS of other plant species, representing perhaps more ancient VvTPS, which have maintained functions independent of speciation.
conclusionsThe highly expanded VvTPS gene family underpins the prominence of terpenoid metabolism in grapevine. We provide a detailed experimental functional annotation of 39 members of this important gene family in grapevine and comprehensive information about gene structure and phylogeny for the entire currently known VvTPS gene family.
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