ArticleThe European journal of neuroscience2010
Polarized targeting of L1-CAM regulates axonal and dendritic bundling in vitro.
Article in The European journal of neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- Context-tuned strategies for marker selection precision in neuronal studies.Frontiers in neuroscience · 2026Review
- Viral delivery of L1CAM promotes axonal extensions by embryonic cerebral grafts in mouse brain.Stem cell reports · 2023Article
- Emergent structural and functional properties of hippocampal multi-cellular aggregates.Frontiers in neuroscience · 2023Article
- Proteomic and functional analyses of the periodic membrane skeleton in neurons.Nature communications · 2022Article
- Article
- Comparative Analysis of the Expression of Chondroitin Sulfate Subtypes and Their Inhibitory Effect on Axonal Growth in the Embryonic, Adult, and Injured Rat Brains.Tissue engineering and regenerative medicine · 2021Article
- Altering Cell-Cell Interaction in Prenatal Alcohol Exposure Models: Insight on Cell-Adhesion Molecules During Brain Development.Frontiers in molecular neuroscience · 2021Review
- ConFiG: Contextual Fibre Growth to generate realistic axonal packing for diffusion MRI simulation.NeuroImage · 2020Article
- Sensory axons inhibit motor axon regeneration in vitro.Experimental neurology · 2020Article
- Pathogenic TFG Mutations Underlying Hereditary Spastic Paraplegia Impair Secretory Protein Trafficking and Axon Fasciculation.Cell reports · 2018Article
- An in vitro model of lissencephaly: expanding the role of DCX during neurogenesis.Molecular psychiatry · 2018Article
- Neuronal Growth and Behavioral Alterations in Mice Deficient for the Psychiatric Disease-AssociatedFrontiers in molecular neuroscience · 2018Article
- Separate transcriptionally regulated pathways specify distinct classes of sister dendrites in a nociceptive neuron.Developmental biology · 2017Article
- Axon tension regulates fasciculation/defasciculation through the control of axon shaft zippering.eLife · 2017Article
- Temporal patterns of gene expression during calyx of held development.Developmental neurobiology · 2016Article
- Genealogical correspondence of a forebrain centre implies an executive brain in the protostome-deuterostome bilaterian ancestor.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Article
- Semi-automatic quantification of neurite fasciculation in high-density neurite images by the neurite directional distribution analysis (NDDA).Journal of neuroscience methods · 2014Article
- Kv3 channel assembly, trafficking and activity are regulated by zinc through different binding sites.The Journal of physiology · 2013Article
- Activation of conventional kinesin motors in clusters by Shaw voltage-gated K+ channels.Journal of cell science · 2013Article
- Lack of serotonin reuptake during brain development alters rostral raphe-prefrontal network formation.Frontiers in cellular neuroscience · 2013Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Proper axonal and dendritic bundling is essential for the establishment of neuronal connections and the synchronization of synaptic inputs, respectively. Cell adhesion molecules of the L1-CAM (L1-cell adhesion molecule) family regulate axon guidance and fasciculation, neuron migration, dendrite morphology, and synaptic plasticity. It remains unclear how these molecules play so many different roles. Here we show that polarized axon-dendrite targeting of an avian L1-CAM protein, NgCAM (neuron-glia cell adhesion molecule), can regulate the switch of bundling of the two major compartments of rat hippocampal neurons. Using a new in-vitro model for studying neurite-neurite interactions, we found that expressed axonal NgCAM induced robust axonal bundling via the trans-homophilic interaction of immunoglobulin domains. Interestingly, dendritic bundling was induced by the dendritic targeting of NgCAM, caused by either deleting its fibronectin repeats or blocking activities of protein kinases. Consistent with the NgCAM results, expression of mouse L1-CAM also induced axonal bundling and blocking kinase activities disrupted its axonal targeting. Furthermore, the trans-homophilic interaction stabilized the bundle formation, probably through recruiting NgCAM proteins to contact sites and promoting guided axon outgrowth. Taken together, our results suggest that precise localization of L1-CAM is important for establishing proper cell-cell contacts in neural circuits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.