ReviewSpringer seminars in immunopathology1990
IgG subclass-restricted immune responses to allergens.
Review in Springer seminars in immunopathology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 35 citations in OpenAlex.
- IgG4 response to fur animal allergens among fur workers.International archives of occupational and environmental health · 2005Trial
- The Complement System Contributes to Functional Antibody-Mediated Responses Induced by Immunization with Plasmodium falciparum Malaria Sporozoites.Infection and immunity · 2018Article
- Immunoglobulin G; structure and functional implications of different subclass modifications in initiation and resolution of allergy.Immunity, inflammation and disease · 2018Review
- Effects of allergic diseases and age on the composition of serum IgG glycome in children.Scientific reports · 2016Article
- Prevalence and isotypic complexity of the anti-Chinese hamster ovary host cell protein antibodies in normal human serum.The AAPS journal · 2010Article
- Role of interleukin 10 in specific immunotherapy.The Journal of clinical investigation · 1998Article
- Epitope-specific T cell tolerance to phospholipase A2 in bee venom immunotherapy and recovery by IL-2 and IL-15 in vitro.The Journal of clinical investigation · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The IgG responses to a variety of allergens are predominated by IgG1 and IgG4 antibodies. With several allergens, the IgG1 response appears to precede the IgG4 response and this switch may be driven by repeated allergen exposure. It remains to be determined whether there is any causal relationship between subclass restriction and the regulation of specific IgE. The question of whether IgG4 antibodies are protective or pathological is still unresolved. Human models are needed to further analyze the interrelationships between T cells, cytokines and B cell isotype expression. The antibody response to allergens appears to be an ideal experimental system for studying antigen-specific isotype regulation in humans. The subclass patterns are remarkably reproducible between individuals, and allergic and normal human subjects, who have been immunized naturally or therapeutically, are readily available as a source of cells. Isolation of allergen-specific T cells that putatively regulate subclass expression would seem to be a worthwhile endeavor. Understanding the molecular and cellular events that initiate and control isotype expression will play an important role in the rational design of immunogens and therapeutics, aimed at optimizing protective immunity and diminishing the pathological effects of autoimmune and allergic responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.