Evidence map›Paper›PMID 20964352›Full record

ReviewMolecular pharmaceutics2010

Targeted imaging and therapy of brain cancer using theranostic nanoparticles.

Mahaveer Swaroop Bhojani, Marcian Van Dort, Alnawaz Rehemtulla, Brian D Ross

Open access · greenAbstract readReview
In one paragraph

Review in Molecular pharmaceutics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 124 citations in OpenAlex.

  1. Article
  2. Response Surface Optimization, Fabrication andPharmaceutical nanotechnology · 2025
    Article
  3. Article
  4. Review
  5. Review
  6. Article
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  8. Review
  9. Review
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  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Theranostic Nanomedicine for Malignant Gliomas.Frontiers in bioengineering and biotechnology · 2019
    Review
  17. Review
  18. Applications of nanoparticle systems in drug delivery technology.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2018
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mahaveer Swaroop BhojaniCenter for Molecular Imaging, Departments of Radiation Oncology and, and Radiology, University of Michigan, Ann Arbor, Michigan 48109, United States.
Marcian Van Dort
Alnawaz Rehemtulla
Brian D Ross
University of Michigan–Ann Arbor · US

Funding

QUANTITATION OF HUMAN BRAIN TUMOR THERAPY RESPONSE BY MRP01CA085878 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ROSS, BRIAN D. · 2001 to 2017
$31.9M
Small Animal Imaging CoreP50CA093990 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ROSS, BRIAN D. · 2002 to 2012
$19.0M
Michigan Small Animal Imaging Resource (MSAIR)U24CA083099 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ROSS, BRIAN D. · 2007 to 2008
$1.3M
NCI NIH HHS P01 CA085878NCI NIH HHS P01CA085878NCI NIH HHS P50 CA093990NCI NIH HHS P50CA093990NCI NIH HHS U24 CA083099NCI NIH HHS U24CA083099
6 · The paper itself

Abstract

The past decade has seen momentous development in brain cancer research in terms of novel imaging-assisted surgeries, molecularly targeted drug-based treatment regimens or adjuvant therapies and in our understanding of molecular footprints of initiation and progression of malignancy. However, mortality due to brain cancer has essentially remained unchanged in the last three decades. Thus, paradigm-changing diagnostic and therapeutic reagents are urgently needed. Nanotheranostic platforms are powerful tools for imaging and treatment of cancer. Multifunctionality of these nanovehicles offers a number of advantages over conventional agents. These include targeting to a diseased site thereby minimizing systemic toxicity, the ability to solubilize hydrophobic or labile drugs leading to improved pharmacokinetics and their potential to image, treat and predict therapeutic response. In this article, we will discuss the application of newer theranostic nanoparticles in targeted brain cancer imaging and treatment.

Indexed as

AnimalsBrain NeoplasmsDiagnostic ImagingHumansNanoparticles

Identifiers

PMID20964352
PMCPMC3291122
OpenAlexW2078458130

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.