ArticleJournal of the American Chemical Society2010
A mechanistic study of electron transfer from the distal termini of electrode-bound, single-stranded DNAs.
Article in Journal of the American Chemical Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 64 citations in OpenAlex.
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- Microscale, Electrochemical, Aptamer-Based Sensors for Enhanced Small-Molecule Detection at Millisecond Time Scales.ACS sensors · 2023Article
- Electrochemical response of surface-attached redox DNA governed by low activation energy electron transfer kinetics.Chemical science · 2023Article
- Sensitive Identification of Microcystin-LR via a Reagent-Free and Reusable Electrochemical Biosensor Using a Methylene Blue-Labeled Aptamer.Biosensors · 2022Article
- 3-D printed microfluidics for rapid prototyping and testing of electrochemical, aptamer-based sensor devices under flow conditions.Analytica chimica acta · 2022Article
- Reagentless biomolecular analysis using a molecular pendulum.Nature chemistry · 2021Article
- Conformational Changes of Immobilized Polythymine due to External Stressors Studied with Temperature-Controlled Electrochemical Microdevices.Langmuir : the ACS journal of surfaces and colloids · 2021Article
- Direct Detection and Discrimination of Nucleotide Polymorphisms Using Anthraquinone Labeled DNA Probes.Frontiers in chemistry · 2020Article
- Understanding Signal and Background in a Thermally Resolved, Single-Branched DNA Assay Using Square Wave Voltammetry.Analytical chemistry · 2018Article
- Calibration-Free Electrochemical Biosensors Supporting Accurate Molecular Measurements Directly in Undiluted Whole Blood.Journal of the American Chemical Society · 2017Article
- Simulation-Based Approach to Determining Electron Transfer Rates Using Square-Wave Voltammetry.Langmuir : the ACS journal of surfaces and colloids · 2017Article
- Reagentless, Structure-Switching, Electrochemical Aptamer-Based Sensors.Annual review of analytical chemistry (Palo Alto, Calif.) · 2016Article
- Rationally designing aptamer sequences with reduced affinity for controlled sensor performance.Sensors (Basel, Switzerland) · 2015Article
- Accurate zygote-specific discrimination of single-nucleotide polymorphisms using microfluidic electrochemical DNA melting curves.Angewandte Chemie (International ed. in English) · 2014Article
- Real-time, aptamer-based tracking of circulating therapeutic agents in living animals.Science translational medicine · 2013Article
- Detection of IP-10 protein marker in undiluted blood serum via an electrochemical E-DNA scaffold sensor.The Analyst · 2013Article
- Entropic and electrostatic effects on the folding free energy of a surface-attached biomolecule: an experimental and theoretical study.Journal of the American Chemical Society · 2012Article
- Design, synthesis, and characterization of nucleic-acid-functionalized gold surfaces for biomarker detection.Langmuir : the ACS journal of surfaces and colloids · 2012Article
- CheapStat: an open-source, "do-it-yourself" potentiostat for analytical and educational applications.PloS one · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Electrode-bound, redox-reporter-modified oligonucleotides play roles in the functioning of a number of electrochemical biosensors, and thus the question of electron transfer through or from such molecules has proven of significant interest. In response, we have experimentally characterized the rate with which electrons are transferred between a methylene blue moiety on the distal end of a short, single-stranded polythymine DNA to a monolayer-coated gold electrode to which the other end of the DNA is site-specifically attached. We find that this rate scales with oligonucleotide length to the -1.16 ± 0.09 power. This weak, approximately inverse length dependence differs dramatically from the much stronger dependencies observed for the rates of end-to-end collisions in single-stranded DNA and through-oligonucleotide electron hopping. It instead coincides with the expected length dependence of a reaction-limited process in which the overall rate is proportional to the equilibrium probability that the end of the oligonucleotide chain approaches the surface. Studies of the ionic strength and viscosity dependencies of electron transfer further support this "chain-flexibility" mechanism, and studies of the electron transfer rate of methylene blue attached to the hexanethiol monolayer suggest that heterogeneous electron transfer through the monolayer is rate limiting. Thus, under the circumstances we have employed, the flexibility (i.e., the equilibrium statistical properties) of the oligonucleotide chain defines the rate with which an attached redox reporter transfers electrons to an underlying electrode, an observation that may be of utility in the design of new biosensor architectures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.