ArticleOrganic letters2010
One-step continuous flow synthesis of highly substituted pyrrole-3-carboxylic acid derivatives via in situ hydrolysis of tert-butyl esters.
Article in Organic letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 78 citations in OpenAlex.
- Three-component reactions of aromatic amines, 1,3-dicarbonyl compounds, and α-bromoacetaldehyde acetal to accessBeilstein journal of organic chemistry · 2020Article
- A Combination of Flow and Batch Mode Processes for the Efficient Preparation of mGluTetrahedron · 2018Article
- Synthesis of α-amino-1,3-dicarbonyl compounds via Ugi flow chemistry reaction: access to functionalized 1,2,3-triazoles.Molecular diversity · 2017Article
- Continuous-flow synthesis of highly functionalized imidazo-oxadiazoles facilitated by microfluidic extraction.Beilstein journal of organic chemistry · 2017Article
- Automated Multistep Continuous Flow Synthesis of 2-(Synthesis · 2012Article
- An Automated Process for a Sequential Heterocycle/Multicomponent Reaction: Multistep Continuous Flow Synthesis of 5-(Thiazol-2-yl)-3,4-Dihydropyrimidin-2(Journal of flow chemistry · 2011Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
The first one-step, continuous flow synthesis of pyrrole-3-carboxylic acids directly from tert-butyl acetoacetates, amines, and 2-bromoketones is reported. The HBr generated as a byproduct in the Hantzsch reaction was utilized in the flow method to hydrolyze the t-butyl esters in situ to provide the corresponding acids in a single microreactor. The protocol was used in the multistep synthesis of pyrrole-3-carboxamides, including two CB1 inverse agonists, directly from commercially available starting materials in a single continuous process.
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