ReviewMammalian genome : official journal of the International Mammalian Genome Society2011
The role of the Major Histocompatibility Complex in the spread of contagious cancers.
Review in Mammalian genome : official journal of the International Mammalian Genome Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 87 citations in OpenAlex.
- Vertical Cancer Transmission via Asexual Fragmentation and Associated Cancer Prevalence.Evolutionary applications · 2025Article
- Approaches and methods to study wildlife cancer.The Journal of animal ecology · 2024Review
- Plethora of New Marsupial Genomes Informs Our Knowledge of Marsupial MHC Class II.Genome biology and evolution · 2024Article
- Horizontal transmission of disseminated neoplasia in the widespread clam Macoma balthica from the Southern Baltic Sea.Molecular ecology · 2022Article
- Article
- Expression of the Nonclassical MHC Class I, Saha-UD in the Transmissible Cancer Devil Facial Tumour Disease (DFTD).Pathogens (Basel, Switzerland) · 2022Article
- Inbreeding Coefficient and Distance in MHC Genes of Parents as Predictors of Reproductive Success in Domestic Cat.Animals : an open access journal from MDPI · 2022Article
- Transmissible Cancers in an Evolutionary Perspective.iScience · 2020Review
- Engineering universal cells that evade immune detection.Nature reviews. Immunology · 2019Review
- The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease.Cancer cell · 2019Article
- MHC diversity and female age underpin reproductive success in an Australian icon; the Tasmanian Devil.Scientific reports · 2018Article
- A systematic approach to cancer: evolution beyond selection.Clinical and translational medicine · 2017Article
- Genetic wealth, population health: Major histocompatibility complex variation in captive and wild ring-tailed lemurs (Ecology and evolution · 2017Article
- Immunoglubolin dynamics and cancer prevalence in Tasmanian devils (Sarcophilus harrisii).Scientific reports · 2016Article
- Transmissible Tumors: Breaking the Cancer Paradigm.Trends in genetics : TIG · 2016Review
- Comment on: 'guidelines for the use of cell lines in biomedical research': human-to-human cancer transmission as a laboratory safety concern.British journal of cancer · 2015Article
- Anthropogenic selection enhances cancer evolution in Tasmanian devil tumours.Evolutionary applications · 2014Article
- A tale of two tumours: comparison of the immune escape strategies of contagious cancers.Molecular immunology · 2013Article
- HLA Class I Allele Frequencies in Southern Iranian Women with Breast Cancer.Iranian journal of basic medical sciences · 2013Article
- Evolution of a contagious cancer: epigenetic variation in Devil Facial Tumour Disease.Proceedings. Biological sciences · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major Histocompatibility Complex (MHC) genes play a key role in immune response to infectious diseases, immunosurveillance, and self/nonself recognition. Matching MHC alleles is critical for organ transplantation, while changes in the MHC profile of tumour cells allow effective evasion of the immune response. Two unique cancers have exploited these features to become transmissible. In this review I discuss the functional role of MHC molecules in the emergence and evolution of Devil Facial Tumour Disease (DFTD) and Canine Transmissible Venereal Tumour (CTVT). High levels of genetic diversity at MHC genes play a critical role in protecting populations of vertebrate species from contagious cancer. However, species that have undergone genetic bottlenecks and have lost diversity at MHC genes are at risk of transmissible tumours. Moreover, evolution and selection for tumour variants capable of evading the immune response allow contagious cancers to cross MHC barriers. Transmissible cancers are rare but they can provide unique insights into the genetics and immunology of tumours and organ transplants.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.