ArticleClinical & experimental metastasis2011
Prognostic significance of claudin expression changes in breast cancer with regional lymph node metastasis.
Article in Clinical & experimental metastasis, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 59 citations in OpenAlex.
- Expression of Claudin-9 (CLDN9) in Breast Cancer, the Clinical Significance in Connection with Its Subcoat Anchorage Proteins ZO-1 and ZO-3 and Impact on Drug Resistance.Biomedicines · 2023Article
- Article
- Cell polarity and cell adhesion associated gene expression differences between invasive micropapillary and no special type breast carcinomas and their prognostic significance.Scientific reports · 2021Article
- E7 oncoprotein from human papillomavirus 16 alters claudins expression and the sealing of epithelial tight junctions.International journal of oncology · 2020Article
- Claudin 1 inhibits cell migration and increases intercellular adhesion in triple-negative breast cancer cell line.Molecular biology reports · 2020Article
- Review
- Intracellular claudin-1 at the invasive front of tongue squamous cell carcinoma is associated with lymph node metastasis.Cancer science · 2020Article
- Afadin cooperates with Claudin-2 to promote breast cancer metastasis.Genes & development · 2019Article
- An emerging role for IQGAP1 in tight junction control.Small GTPases · 2018Review
- Article
- The role of claudins in cancer metastasis.Oncogene · 2017Review
- Claudin-1 Protein Expression Is a Good Prognostic Factor in Non-Small Cell Lung Cancer, but only in Squamous Cell Carcinoma Cases.Pathology oncology research : POR · 2017Article
- Overexpression of Claudin-1 is Associated with Advanced Clinical Stage and Invasive Pathologic Characteristics of Oral Squamous Cell Carcinoma.Head and neck pathology · 2015Article
- Lyn modulates Claudin-2 expression and is a therapeutic target for breast cancer liver metastasis.Oncotarget · 2015Article
- IQGAP1 controls tight junction formation through differential regulation of claudin recruitment.Journal of cell science · 2015Article
- Correlation of NGX6 expression with clinicopathologic features and prognosis in colon cancer.International journal of clinical and experimental medicine · 2015Article
- Article
- Strong claudin 5 expression is a poor prognostic sign in pancreatic adenocarcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Prostate apoptosis response-4 mediates TGF-β-induced epithelial-to-mesenchymal transition.Cell death & disease · 2014Article
- Claudin-2 is an independent negative prognostic factor in breast cancer and specifically predicts early liver recurrences.Molecular oncology · 2014Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adherent and tight junction molecules have been described to contribute to carcinogenesis and tumor progression. Additionally, the group of claudin-low tumors have recently been identified as a molecular subgroup of breast carcinoma. In our study, we examined the expression pattern of claudins, beta-catenin and E-cadherin in invasive ductal (IDCs) and lobular (ILCs) carcinomas and their corresponding lymph node metastases (LNMs). Tissue microarrays of 97 breast samples (60 invasive ductal carcinomas, 37 invasive lobular carcinomas) and their corresponding LNMs have been analyzed immunohistochemically for claudin-1, -2, -3, -4, -5, -7, beta-catenin and E-cadherin expression. The stained slides were digitalized with a slide scanner and the reactions were evaluated semiquantitatively. When compared to LNMs, in the IDC group beta-catenin and claudin-2, -3, -4 and -7 protein expression showed different pattern while claudin-1, -2, -3, -4 and -7 were differently expressed in the ILC group. Lymph node metastases developed a notable increase of claudin-5 expression in both groups. Decrease or loss of claudin-1 and expression of claudin-4 in lymph node metastases correlated with reduced disease-free survival in our patients. According to our observations, the expression of epithelial junctional molecules, especially claudins, is different in primary breast carcinomas compared to their lymph node metastases as demonstrated by immunohistochemistry. Loss of claudin junctional molecules might contribute to tumor progression, and certain claudin expression pattern might be of prognostic relevance.
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