ArticleHuman genetics2011
Genome-scan for IQ discrepancy in autism: evidence for loci on chromosomes 10 and 16.
Article in Human genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Genomic insights and advanced machine learning: characterizing autism spectrum disorder biomarkers and genetic interactions.Metabolic brain disease · 2024Pooled it
- Autism Spectrum Disorder: The Cerebellum, Genes, and Pathways.Neurology international · 2025Review
- Integrating causal discovery and clinically-relevant insights to explore directional relationships between autistic features, sex at birth, and cognitive abilities.Psychological medicine · 2025Article
- Classical cadherins evolutionary constraints in primates is associated with their expression in the central nervous system.PloS one · 2024Article
- Cognitive correlates of autism spectrum disorder symptoms.Autism research : official journal of the International Society for Autism Research · 2021Article
- The Hidden Side of NCAM Family: NCAM2, a Key Cytoskeleton Organization Molecule Regulating Multiple Neural Functions.International journal of molecular sciences · 2021Review
- Prevalence and Risk Factors of Anxiety in a Clinical Dutch Sample of Children with an Autism Spectrum Disorder.Frontiers in psychiatry · 2018Article
- Cadherin 13: humanMolecular medicine (Cambridge, Mass.) · 2016Article
- Variants in Adjacent Oxytocin/Vasopressin Gene Region and Associations with ASD Diagnosis and Other Autism Related Endophenotypes.Frontiers in neuroscience · 2016Article
- A Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons.Frontiers in cellular neuroscience · 2016Review
- Whole exome sequencing in extended families with autism spectrum disorder implicates four candidate genes.Human genetics · 2015Article
- Cognitive Profiles in Youth with Autism Spectrum Disorder: An Investigation of Base Rate Discrepancies using the Differential Ability Scales--Second Edition.Journal of autism and developmental disorders · 2015Article
- Intercellular protein-protein interactions at synapses.Protein & cell · 2014Review
- Identification of risk genes for autism spectrum disorder through copy number variation analysis in Austrian families.Neurogenetics · 2014Article
- Reduction in retinal nerve fiber layer thickness in young adults with autism spectrum disorders.Journal of autism and developmental disorders · 2014Article
- A genome scan for loci shared by autism spectrum disorder and language impairment.The American journal of psychiatry · 2014Article
- Using IQ discrepancy scores to examine the neural correlates of specific cognitive abilities.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Individual common variants exert weak effects on the risk for autism spectrum disorders.Human molecular genetics · 2012Article
- Parsing heterogeneity in autism spectrum disorders: visual scanning of dynamic social scenes in school-aged children.Journal of the American Academy of Child and Adolescent Psychiatry · 2012Article
- Evidence for involvement of GNB1L in autism.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2012Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
Performance IQ (PIQ) greater than verbal IQ (VIQ) is often observed in studies of the cognitive abilities of autistic individuals. This characteristic is correlated with social and communication impairments, key parts of the autism diagnosis. We present the first genetic analyses of IQ discrepancy (PIQ-VIQ) as an autism-related phenotype. We performed genome-wide joint linkage and segregation analyses on 287 multiplex families, using a Markov chain Monte Carlo approach. Genetic data included a genome-scan of 387 micro-satellite markers in 210 families augmented with additional markers added in a subset of families. Empirical P values were calculated for five interesting regions. Linkage analysis identified five chromosomal regions with substantial regional evidence of linkage; 10p12 [P = 0.001; genome-wide (gw) P = 0.05], 16q23 (P = .015; gw P = 0.53), 2p21 (P = 0.03, gw P = 0.78), 6q25 (P = 0.047, gw P = 0.91) and 15q23-25 (P = 0.053, gw P = 0.93). The location of the chromosome 10 linkage signal coincides with a region noted in a much earlier genome-scan for autism, and the chromosome 16 signal coincides exactly with a linkage signal for non-word repetition in specific language impairment. This study provides strong evidence for a QTL influencing IQ discrepancy in families with autistic individuals on chromosome 10, and suggestive evidence for a QTL on chromosome 16. The location of the chromosome 16 signal suggests a candidate gene, CDH13, a T-cadherin expressed in the brain, which has been implicated in previous SNP studies of autism and ADHD.
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Registered trials
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