ReviewDeutsches Arzteblatt international2010
New developments in the diagnosis of dementia.
Review in Deutsches Arzteblatt international, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Using event-related potential P300 as an electrophysiological marker for differential diagnosis and to predict the progression of mild cognitive impairment: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2015Pooled it
- Plasma amyloid-β as a predictor of dementia and cognitive decline: a systematic review and meta-analysis.Archives of neurology · 2012Pooled it
- Determining the metabolic profile measured using ultra-high pressure liquid chromatography associated with Beta Amyloid burden in the brain in individuals with mild cognitive impairment.Research square · 2026Article
- Beyond Transgenic Mice: Emerging Models and Translational Strategies in Alzheimer's Disease.International journal of molecular sciences · 2025Review
- Deep learning reveals pathology-confirmed neuroimaging signatures in Alzheimer's, vascular and Lewy body dementias.Brain : a journal of neurology · 2025Article
- Modelling Neurological Diseases in Large Animals: Criteria for Model Selection and Clinical Assessment.Cells · 2022Review
- Manipulation of the diet-microbiota-brain axis in Alzheimer's disease.Frontiers in neuroscience · 2022Review
- Associations between social burden, perceived stress, and diurnal cortisol profiles in older adults: implications for cognitive aging.European journal of ageing · 2021Article
- Pharmacological Targets and the Biological Mechanisms of Formononetin for Alzheimer's Disease: A Network Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Senile Dementia from Neuroscientific and Islamic Perspectives.Journal of religion and health · 2018Article
- [Diagnostics and multimodal treatment of depression in old age : New developments].Zeitschrift fur Gerontologie und Geriatrie · 2017Review
- Effects of interventions on physical activity in nursing home residents.European journal of ageing · 2015Review
- Frequency of dementia syndromes with a potentially treatable cause in geriatric in-patients: analysis of a 1-year interval.European archives of psychiatry and clinical neuroscience · 2015Article
- Brain PET in the diagnosis of Alzheimer's disease.Clinical nuclear medicine · 2014Review
- Back propagation artificial neural network for community Alzheimer's disease screening in China.Neural regeneration research · 2013Article
- Preclinical non-human models to combat dementia.Annals of neurosciences · 2013Review
- Initial mini-mental state and cerebral perfusion in Alzheimer's disease.Clinical neuroradiology · 2012Article
- Effects of hypoperfusion in Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2011Review
- The investigation and differential diagnosis of dementias.Deutsches Arzteblatt international · 2010Article
- Diagnosis of Alzheimer's disease in Brazil: Supplementary exams.Dementia & neuropsychologiaReview
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4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe terms "dementia" and "Alzheimer's disease" are often wrongly used as if they were synonyms. Dementia is a clinical syndrome whose main element is memory impairment; it is due to Alzheimer's disease in more than 75% of cases. Alzheimer's disease, on the other hand, is a neuropathological entity that is characterized by a protracted preclinical phase followed by the onset of slowly progressive dementia.
methodsWe here review relevant literature that we retrieved by a selective Medline search (2005-2009), paying special attention to the early diagnosis of Alzheimer's disease, its clinical manifestations, and its relevance in primary care.
resultsThe early clinical manifestations of a dementing illness can be detected in primary care through the use of simple screening tests such as the mini mental state examination, clock drawing tests, and DemTect. A diminished concentration of Abeta-peptide and an increase of (phospho-)tau in the cerebrospinal fluid can suggest the presence of Alzheimer's disease even before the onset of dementia: these substances are components of amyloid plaques and neurofibrillary tangles, which are the characteristic neuropathological lesions of Alzheimer's disease. New types of morphological magnetic resonsance imaging (MRI), and automated analysis of the images obtained, can improve the consistency of radiological assessment over the traditional visual method and thus enable more secure diagnosis.
conclusionThe early, preclinical phase of Alzheimer's disease involves what has been termed mild cognitive impairment and may last as long as five years until the onset of dementia. With the aid of the new biomarkers described here, the likelihood of diagnosing Alzheimer's disease correctly in this phase can be raised above 80%. Early detection of Alzheimer's disease before the onset of dementia provides an opportunity to study potential approaches for secondary prevention, which are now an object of intense clinical research.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.