ArticleThe ISME journal2011
Phylogenetic and gene-centric metagenomics of the canine intestinal microbiome reveals similarities with humans and mice.
Article in The ISME journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 191 papers, 1 of them a synthesis that pooled it.
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Who cites it
191 citing papers in PubMed, 1 synthesis or guideline pooled it, 418 citations in OpenAlex.
- How informative is the mouse for human gut microbiota research?Disease models & mechanisms · 2015Pooled it
- Dietary geraniol ameliorates intestinal dysbiosis and relieves symptoms in irritable bowel syndrome patients: a pilot study.BMC complementary and alternative medicine · 2018Trial
- Raw meat based diet influences faecal microbiome and end products of fermentation in healthy dogs.BMC veterinary research · 2017Trial
- Trial
- Neither vaginal nor buccal administration of 800 μg misoprostol alters mucosal and systemic immune activation or the cervicovaginal microbiome: a pilot study.The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception · 2016Trial
- Alterations in ileal mucosa bacteria related to diet complexity and growth performance in young pigs.PloS one · 2014Trial
- Effects of dietary cooked navy bean on the fecal microbiome of healthy companion dogs.PloS one · 2013Trial
- Evaluation ofJournal of animal science and technology · 2026Article
- PPARα deficiency causes skin dysbiosis and triggers innate immunity in keratinocytes.Cell death & disease · 2026Article
- Article
- Oral administration of recombinant Bacillus subtilis spores induces protective immunity against Echinococcus granulosus infection in dogs.Parasites & vectors · 2025Article
- Effects ofMicroorganisms · 2025Article
- Natural Microbiota of Dogs and Cats as a Source and Vector of Resistance Genes-Clinical Significance.International journal of molecular sciences · 2025Review
- Microbial Interconnections in One Health: A Critical Nexus Between Companion Animals and Human Microbiomes.Microorganisms · 2025Review
- DRAMMA: a multifaceted machine learning approach for novel antimicrobial resistance gene detection in metagenomic data.Microbiome · 2025Article
- Anti-Obesity Potential of Barley Sprouts in Dog Diets and Their Impact on the Gut Microbiota.Microorganisms · 2025Article
- Exploring Gut Microbiota-Targeted Therapies for Canine Idiopathic Epilepsy.International journal of molecular sciences · 2025Review
- Pathogen Detection and Resistome Analysis in Healthy Shelter Dogs Using Whole Metagenome Sequencing.Pathogens (Basel, Switzerland) · 2025Article
- Effects of corn protein inclusion on apparent total tract macronutrient digestibility, palatability, and fecal characteristics, microbiota, and metabolites of healthy adult dogs.Journal of animal science · 2025Article
- Effects of Bacillus coagulans (GBI-30, 6086) supplementation on apparent total tract nutrient digestibility and the fecal characteristics and metabolites, immunity, and microbiota of healthy adult dogs.Journal of animal science · 2025Article
131 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study is the first to use a metagenomics approach to characterize the phylogeny and functional capacity of the canine gastrointestinal microbiome. Six healthy adult dogs were used in a crossover design and fed a low-fiber control diet (K9C) or one containing 7.5% beet pulp (K9BP). Pooled fecal DNA samples from each treatment were subjected to 454 pyrosequencing, generating 503,280 (K9C) and 505,061 (K9BP) sequences. Dominant bacterial phyla included the Bacteroidetes/Chlorobi group and Firmicutes, both of which comprised ∼35% of all sequences, followed by Proteobacteria (13-15%) and Fusobacteria (7-8%). K9C had a greater percentage of Bacteroidetes, Fusobacteria and Proteobacteria, whereas K9BP had greater proportions of the Bacteroidetes/Chlorobi group and Firmicutes. Archaea were not altered by diet and represented ∼1% of all sequences. All archaea were members of Crenarchaeota and Euryarchaeota, with methanogens being the most abundant and diverse. Three fungi phylotypes were present in K9C, but none in K9BP. Less than 0.4% of sequences were of viral origin, with >99% of them associated with bacteriophages. Primary functional categories were not significantly affected by diet and were associated with carbohydrates; protein metabolism; DNA metabolism; cofactors, vitamins, prosthetic groups and pigments; amino acids and derivatives; cell wall and capsule; and virulence. Hierarchical clustering of several gastrointestinal metagenomes demonstrated phylogenetic and metabolic similarity between dogs, humans and mice. More research is required to provide deeper coverage of the canine microbiome, evaluate effects of age, genetics or environment on its composition and activity, and identify its role in gastrointestinal disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.