ArticleJournal of human hypertension2011
The diverse associations of uric acid with low-grade inflammation, adiponectin and arterial stiffness in never-treated hypertensives.
Article in Journal of human hypertension, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Association of serum uric acid with mortality and cardiovascular outcomes in patients with hypertension: a meta-analysis.Journal of thrombosis and thrombolysis · 2021Pooled it
- Comparison of the effects of metoprolol or carvedilol on serum gamma-glutamyltransferase and uric acid levels among patients with acute coronary syndrome without ST segment elevation.Anatolian journal of cardiology · 2016Trial
- Changes in uric acid metabolism and associated plasma proteomics during sex hormone therapy.Journal of clinical & translational endocrinology · 2026Article
- Assessing the Causal Effects of Adipokines on Uric Acid and Gout: A Two-Sample Mendelian Randomization Study.Nutrients · 2022Article
- Clinical effectiveness and safety of amlodipine/losartan-based single-pill combination therapy in patients with hypertension: Findings from real-world, multicenter observational databases.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Expanding role for single-pill combination drug therapy in the initial treatment of hypertension?Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Uric Acid and Arterial Stiffness.Therapeutics and clinical risk management · 2020Review
- Adipokines and Arterial Stiffness in the Elderly.Vascular health and risk management · 2020Article
- Uric acid upregulates the adiponectin‑adiponectin receptor 1 pathway in renal proximal tubule epithelial cells.Molecular medicine reports · 2018Article
- The baseline levels and risk factors for high-sensitive C-reactive protein in Chinese healthy population.Immunity & ageing : I & A · 2018Article
- Atherogenic Index in Type 2 Diabetes and Its Relationship with Chronic Microvascular Complications.International journal of endocrinology · 2018Article
- Article
- Serum uric acid is associated with arterial stiffness in men with newly diagnosed type 2 diabetes mellitus.Journal of endocrinological investigation · 2014Article
- Xanthine oxidase and cardiovascular risk in obese children.Childhood obesity (Print) · 2014Article
- Interaction of inflammation, hyperuricemia, and the prevalence of hypertension among adults free of metabolic syndrome: NHANES 2009-2010.Journal of the American Heart Association · 2014Article
- The role of tissue Renin-Angiotensin-aldosterone system in the development of endothelial dysfunction and arterial stiffness.Frontiers in endocrinology · 2013Review
- Associations of serum uric acid levels with arterial wave reflections and central systolic blood pressure.International journal of cardiology · 2013Article
- Relationship between serum uric acid and internal carotid resistive index in hypertensive women: a cross-sectional study.BMC cardiovascular disorders · 2012Article
- Article
- Serum uric Acid level and diverse impacts on regional arterial stiffness and wave reflection.Iranian journal of public health · 2012Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The data regarding the role of serum uric acid (SUA) along with subclinical inflammation in the context of hypertensive vascular damage are rather scarce and controversial. Towards this end, we assess the links between SUA, high-sensitivity CRP (hs-CRP), adiponectin and carotid to femoral pulse wave velocity (c-f PWV) in 292 subjects with never-treated stage I-II essential hypertension. On the basis of the median SUA levels (0.31 mmol l(-1)), the study population was divided into subjects with low (n=149) and high (n=143) SUA values. By multiple regression analysis, it was revealed that SUA was independently associated with log hs-CRP (R(2)=0.098; P=0.02), log adiponectin (R(2)=0.102; P=0.03), waist circumference (R(2)=0.049; P=0.04), 24-h systolic blood pressure (SBP) (R(2)=0.179; P=0.001) and estimated glomerular filtration rate (R(2)=0.156; β (s.e.)=-0.169 (0.023); P=0.02). In addition, c-f PWV was independently associated with age (R(2)=0.116; P<0.0001), waist circumference (R(2)=0.088; P<0.0001), 24-h SBP (R(2)=0.167; P=0.001), log adiponectin (R(2)=0.07; P=0.006) and log hs-CRP (R(2)=0.06; P=0.034). In conclusion, SUA levels are independently associated with hs-CRP and adiponectin levels but not with c-f PWV in essential hypertensive patients. Increased SUA levels are accompanied by a state of pronounced inflammatory activation and hypoadiponectinemia that significantly impairs the arterial stiffness accelerating the vascular ageing process in this setting.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.