ArticleEpigenetics2011
Conservation and divergence of DNA methylation in eukaryotes: new insights from single base-resolution DNA methylomes.
Article in Epigenetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 71 citations in OpenAlex.
- Reliable investigation of DNA methylation using Oxford nanopore technologies.Scientific reports · 2025Article
- Deep5mC: Predicting 5-methylcytosine (5mC) methylation status using a deep learning transformer approach.Computational and structural biotechnology journal · 2025Article
- The Whole Genome DNA Methylation Signatures of Hindlimb Muscles in Chinese Alligators during Hibernation and Active Periods.Animals : an open access journal from MDPI · 2024Article
- Interplay between gene expression and gene architecture as a consequence of gene and genome duplications: evidence from metabolic genes ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2022Article
- Article
- Epigenetic Distribution of Recombinant Plant Chromosome Fragments in a Human-International journal of molecular sciences · 2021Article
- Identification of Putative Virulence Genes by DNA Methylation Studies in the Cereal PathogenCells · 2021Article
- The Impact of DNA Methylation Dynamics on the Mutation Rate During Human Germline Development.G3 (Bethesda, Md.) · 2020Article
- Distinct Expression and Methylation Patterns for Genes with Different Fates following a Single Whole-Genome Duplication in Flowering Plants.Molecular biology and evolution · 2020Article
- A Unique Energy-Saving Strategy during Hibernation Revealed by Multi-Omics Analysis in the Chinese Alligator.iScience · 2020Article
- DNA methylation analysis in plants: review of computational tools and future perspectives.Briefings in bioinformatics · 2020Review
- Structural adaptation of vertebrate endonuclease G for 5-hydroxymethylcytosine recognition and function.Nucleic acids research · 2020Article
- The Pattern and Function of DNA Methylation in Fungal Plant Pathogens.Microorganisms · 2020Review
- Diversity of Fungal DNA Methyltransferases and Their Association With DNA Methylation Patterns.Frontiers in microbiology · 2020Review
- Article
- Whole Genome Incorporation and Epigenetic Stability in a Newly Synthetic Allopolyploid of Gynogenetic Gibel Carp.Genome biology and evolution · 2018Article
- Genome-wide DNA methylomes from discrete developmental stages reveal the predominance of non-CpG methylation in Tribolium castaneum.DNA research : an international journal for rapid publication of reports on genes and genomes · 2017Article
- Methylation profile of a satellite DNA constituting the intercalary G+C-rich heterochromatin of the cut trough shell Spisula subtruncata (Bivalvia, Mactridae).Scientific reports · 2017Article
- The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with Schistosoma mansoni.PLoS neglected tropical diseases · 2017Article
- Circulating MicroRNAs and Life Expectancy Among Identical Twins.Annals of human genetics · 2016Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
DNA methylation is one of the most important heritable epigenetic modifications of the genome and is involved in the regulation of many cellular processes. Aberrant DNA methylation has been frequently reported to influence gene expression and subsequently cause various human diseases, including cancer. Recent rapid advances in next-generation sequencing technologies have enabled investigators to profile genome methylation patterns at single-base resolution. Remarkably, more than 20 eukaryotic methylomes have been generated thus far, with a majority published since November 2009. Analysis of this vast amount of data has dramatically enriched our knowledge of biological function, conservation and divergence of DNA methylation in eukaryotes. Even so, many specific functions of DNA methylation and their underlying regulatory systems still remain unknown to us. Here, we briefly introduce current approaches for DNA methylation profiling and then systematically review the features of whole genome DNA methylation patterns in eight animals, six plants and five fungi. Our systematic comparison provides new insights into the conservation and divergence of DNA methylation in eukaryotes and their regulation of gene expression. This work aims to summarize the current state of available methylome data and features informatively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.