ArticleProceedings of the National Academy of Sciences of the United States of America2010
Relevance of synaptic tagging and capture to the persistence of long-term potentiation and everyday spatial memory.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
118 citing papers in PubMed, 254 citations in OpenAlex.
- Methylphenidate during early consolidation affects long-term associative memory retrieval depending on baseline catecholamines.Psychopharmacology · 2017Trial
- Prior novelty invigorates future mesolimbic target detection.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Integrating Aversive Memories in the Basolateral Amygdala.Biological psychiatry · 2025Review
- Prior Novelty Invigorates Future Mesolimbic Target Detection.bioRxiv : the preprint server for biology · 2025Article
- Modelling of What-Where-When Everyday Memories in Rats.The European journal of neuroscience · 2025Article
- Activation of Locus Coeruleus-Hippocampus Tyrosine Hydroxylase Projection Contributes to the Surgical Incision Pain-Induced Memory Consolidation Enhancement in Mice.CNS neuroscience & therapeutics · 2025Article
- Beyond boundaries: extended temporal flexibility in synaptic tagging and capture.Communications biology · 2025Article
- Memory persistence enhancement by post-learning moderate exercise requires de novo protein synthesis in the dorsal hippocampus.PloS one · 2025Article
- Linking new information to a short-lasting memory trace induces consolidation in the hippocampus.iScience · 2024Article
- Light-exercise-induced dopaminergic and noradrenergic stimulation in the dorsal hippocampus: Using a rat physiological exercise model.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Hippocampal contextualization of social rewards in mice.Nature communications · 2024Article
- Blockade of dopamine D3 receptors improves hippocampal synaptic function and rescues age-related cognitive phenotype.Aging cell · 2024Article
- Active forgetting and neuropsychiatric diseases.Molecular psychiatry · 2024Review
- Event boundaries drive norepinephrine release and distinctive neural representations of space in the rodent hippocampus.bioRxiv : the preprint server for biology · 2024Article
- The role of calcium stores in long-term potentiation and synaptic tagging and capture in mouse hippocampus.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Synapses tagged, memories kept: synaptic tagging and capture hypothesis in brain health and disease.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Engram mechanisms of memory linking and identity.Nature reviews. Neuroscience · 2024Review
- Ventral tegmental area dopamine projections to the hippocampus trigger long-term potentiation and contextual learning.Nature communications · 2024Article
- Rodent maze studies: from following simple rules to complex map learning.Brain structure & function · 2024Review
- Apoptosis signal-regulating kinase 1 (Frontiers in cellular neuroscience · 2024Article
58 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Memory for inconsequential events fades, unless these happen before or after other novel or surprising events. However, our understanding of the neurobiological mechanisms of novelty-enhanced memory persistence is mainly restricted to aversive or fear-associated memories. We now outline an "everyday appetitive" behavioral model to examine whether and how unrelated novelty facilitates the persistence of spatial memory coupled to parallel electrophysiological studies of the persistence of long-term potentiation (LTP). Across successive days, rats were given one trial per day to find food in different places and later had to recall that day's location. This task is both hippocampus and NMDA receptor dependent. First, encoding with low reward induced place memory that decayed over 24 h; in parallel, weak tetanization of CA1 synapses in brain slices induced early-LTP fading to baseline. Second, novelty exploration scheduled 30 min after this weak encoding resulted in persistent place memory; similarly, strong tetanization--analogous to novelty--both induced late-LTP and rescued early- into late-LTP on an independent but convergent pathway. Third, hippocampal dopamine D1/D5 receptor blockade or protein synthesis inhibition within 15 min of exploration prevented persistent place memory and blocked late-LTP. Fourth, symmetrically, when spatial memory was encoded using strong reward, this memory persisted for 24 h unless encoding occurred under hippocampal D1/D5 receptor blockade. Novelty exploration before this encoding rescued the drug-induced memory impairment. Parallel effects were observed in LTP. These findings can be explained by the synaptic tagging and capture hypothesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.