ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2010
Regulation of sFlt-1 and VEGF secretion by adenosine under hypoxic conditions in rat placental villous explants.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Potential role of A2B adenosine receptors on proliferation/migration of fetal endothelium derived from preeclamptic pregnancies.BioMed research international · 2014Trial
- Linking TLR-7 Signaling to Downregulation of Placental P-Glycoprotein: Implications for Fetal Drug Exposure.Pharmaceutics · 2025Article
- AMP-activated protein kinase activator AICAR attenuates hypoxia-induced murine fetal growth restriction in part by improving uterine artery blood flow.The Journal of physiology · 2020Article
- Review
- Role of the NLRP3 Inflammasome in Preeclampsia.Frontiers in endocrinology · 2020Review
- Acute Hypoxia and Chronic Ischemia Induce Differential Total Changes in Placental Epigenetic Modifications.Reproductive sciences (Thousand Oaks, Calif.) · 2019Article
- Targeting A2 adenosine receptors in cancer.Immunology and cell biology · 2017Review
- Vascular Endothelial Growth Factor and Podocyte Protection in Chronic Hypoxia: Effects of Endothelin-A Receptor Antagonism.American journal of nephrology · 2016Article
- Adenosine A2B receptor stimulates angiogenesis by inducing VEGF and eNOS in human microvascular endothelial cells.Experimental biology and medicine (Maywood, N.J.) · 2015Article
- Hypoxia-Mediated Soluble Fms-Like Tyrosine Kinase 1 Increase Is Not Attenuated in Interleukin 6-Deficient Mice.Reproductive sciences (Thousand Oaks, Calif.) · 2015Article
- Elevated placental adenosine signaling contributes to the pathogenesis of preeclampsia.Circulation · 2015Article
- New approaches for managing preeclampsia: clues from clinical and basic research.Clinical therapeutics · 2014Review
- Endometrial VEGF induces placental sFLT1 and leads to pregnancy complications.The Journal of clinical investigation · 2014Article
- Methodological differences account for inconsistencies in reported free VEGF concentrations in pregnant rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Pregnancy morbidity in antiphospholipid syndrome: what is the impact of treatment?Current rheumatology reports · 2014Review
- Maternally sequestered therapeutic polypeptides - a new approach for the management of preeclampsia.Frontiers in pharmacology · 2014Article
- Impaired adenosine-mediated angiogenesis in preeclampsia: potential implications for fetal programming.Frontiers in pharmacology · 2014Review
- Impaired A2A adenosine receptor/nitric oxide/VEGF signaling pathway in fetal endothelium during late- and early-onset preeclampsia.Purinergic signalling · 2013Article
- AICAR administration ameliorates hypertension and angiogenic imbalance in a model of preeclampsia in the rat.American journal of physiology. Heart and circulatory physiology · 2013Article
- Exercise training attenuates placental ischemia-induced hypertension and angiogenic imbalance in the rat.Hypertension (Dallas, Tex. : 1979) · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The role of adenosine in the regulation of cardiovascular function has long been acknowledged, but only recently has its importance in angiogenesis been appreciated, most notably, through its direct regulation of the proangiogenic growth factor, VEGF. Recent work has established that proangiogenic and antiangiogenic factors, specifically VEGF and and the soluble VEGF receptor fms-like tyrosine kinase-1 (sFlt-1), are directly influenced by hypoxia in placental ischemia. While adenosine has been reported to be an important regulator of VEGF in vascular tissue, the importance of adenosine in regulating VEGF and sFlt-1 in placental tissue is unclear. Here, we have investigated the role of adenosine in the secretion of VEGF and the antiangiogenic protein sFlt-1 in placental villous explants. Under normoxic conditions (6% oxygen), the nonspecific adenosine receptor antagonist, 8-sulphophenyltheophylline (8-SPT) had no effect on either VEGF (P = 0.38) or sFlt-1 (P = 0.56) secretion. However, under hypoxic conditions (1% oxygen), 8-SPT attenuated the increase in the secretion of both VEGF and sFlt-1 (P < 0.05 and P < 0.005, respectively). Exogenous and the adenosine transporter inhibitor dipyridamole (which increases extracellular levels of adenosine) showed differential effects under normoxic conditions: sFlt-1 levels in media increased significantly (P < 0.05), whereas VEGF was unaffected (P = 0.67 and P = 0.19, respectively). These data indicate that extracellular adenosine can regulate VEGF and sFlt-1 secretion in the hypoxic placenta and could, therefore, control the balance of these competing angiogenic factors in diseases characterized by placental ischemia.
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Registered trials
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