Evidence map›Paper›PMID 20962018›Full record

ArticleThe Journal of clinical endocrinology and metabolism2011

The metabolic phenotype of Prader-Willi syndrome (PWS) in childhood: heightened insulin sensitivity relative to body mass index.

Andrea M Haqq, Michael J Muehlbauer, Christopher B Newgard, Steven Grambow, Michael Freemark

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02011360 (Evidence-Based Approach to Dietary Management of Prader-Willi Syndrome), which is not on this map. Cited by 59 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02011360 nacompletednot on this mapstarted 2014, after this paper: background citation

Evidence-Based Approach to Dietary Management of Prader-Willi Syndrome (PWS)

TypeinterventionalSponsorDuke UniversityRan2014 to 2016Enrolled10ConditionsPrader Willi Syndrome, Syndromic Obesity, Childhood ObesityArmsLow Carbohydrate diet, Low Fat diet
3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrea M HaqqDivision of Pediatric Endocrinology, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada. andrea.haqq@albertahealthservices.ca
Michael J Muehlbauer
Christopher B Newgard
Steven Grambow
Michael Freemark

Funding

Developmental, nutritional and hormonal reg. of GhrelinK23RR021979 · NCRR · DUKE UNIVERSITY · PI HAQQ, ANDREA M · 2005 to 2008
$551k
NCRR NIH HHS 1K23-RR-021979NCRR NIH HHS K23 RR021979
6 · The paper itself

Abstract

contextInsulin sensitivity is higher in patients with Prader-Willi syndrome (PWS) than in body mass index-matched obese controls (OCs). Factors contributing to the heightened insulin sensitivity of PWS remain obscure. We compared the fasting levels of various hormones, cytokines, lipids, and liver function tests in 14 PWS patients and 14 OCs with those in 14 age- and gender-matched lean children (LC). We hypothesized that metabolic profiles of children with PWS are comparable with those of LC, but different from those of OCs.

resultsLeptin levels were comparable in PWS patients and OCs, suggesting comparable degrees of adiposity. Glucose levels were comparable among groups. However, fasting insulin concentrations and homeostasis model assessment insulin resistance index were lower in PWS patients than in OCs (P < 0.05) and similar to LC. Moreover, high-density lipoprotein levels were lower and triglycerides higher in OCs (P < 0.05) but not PWS patients. Total adiponectin, high-molecular-weight (HMW) adiponectin and the HMW to total adiponectin ratio were higher in PWS patients (P < 0.05) than in OCs and similar to LC. High-sensitivity C-reactive protein and IL-6 levels were higher in OCs than in PWS patients or LC (P < 0.05). Nevertheless, PAI-1 levels were elevated in both OC and PWS patients. There were no group differences in glucagon-like peptide-1, macrophage chemoattractant protein-1, TNFα, IL-2, IL-8, IL-10, IL-12p40, IL-18, resistin, total or low-density lipoprotein cholesterol, aspartate aminotransferase, or alanine aminotransferase.

conclusionsThe heightened insulin sensitivity of PWS patients relative to OCs is associated with higher levels of adiponectin and lower levels of high-sensitivity C-reactive protein and IL-6. Future studies will determine whether PWS children are protected from obesity comorbidities such as type 2 diabetes, hyperlipidemia, and nonalcoholic fatty liver disease.

Indexed as

Blood GlucoseBody Mass IndexChildCytokinesHumansInsulinInsulin ResistanceLeptinPrader-Willi SyndromeBlood GlucoseCytokinesInsulinLeptin

Identifiers

PMID20962018
PMCPMC3038476

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.