ArticleThe Journal of physiology2010
Regulation of exocytic mode in hippocampal neurons by intra-bouton calcium concentration.
Article in The Journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Formation, Organization, and Maintenance of Synaptic Vesicle Pools: From Molecules to Structure and Dynamics.Advances in neurobiology · 2026Review
- Synaptic Vesicle Recycling Through the Lens of Ultrafast Endocytosis.Annual review of neuroscience · 2025Review
- Considerations for Measuring Activity-Dependence of Recruitment of Synaptic Vesicles to the Readily Releasable Pool.Frontiers in synaptic neuroscience · 2019Review
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1 author.
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Abstract
Release of neurotransmitters from synaptic vesicles is a central event in synaptic transmission. Recent evidence suggests that synaptic vesicles fuse with the plasma membrane by multiple routes during exocytosis, but the regulation and physiological implications of this choice are unclear. At hippocampal synapses in culture, two modes of synaptic vesicle exocytosis can be distinguished by virtue of the rate and extent of loss of a fluorescent lipid marker (FM1-43). Here we investigate these two modes of exocytosis using fluorescence imaging of FM1-43, combined with quantitative Ca(2+) imaging using Oregon green BAPTA-1 (OGB1), to examine how the balance of exocytic mode changes during a stimulus train. Our findings are twofold: that the full fusion mode becomes progressively favoured through the course of a 5 or 10 Hz stimulus train, and that this occurs in parallel with presynaptic accumulation of calcium. Blockade of calcium accumulation with AM-EGTA also prevents the conversion of exocytic mode. This conversion of exocytic mode may provide insight as to the mechanisms underpinning short term plasticity.
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