ArticleCold Spring Harbor perspectives in biology2011
A compendium of the mouse mammary tumor biologist: from the initial observations in the house mouse to the development of genetically engineered mice.
Article in Cold Spring Harbor perspectives in biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 48 citations in OpenAlex.
- Unlocking Translational Potential: Conditionally Reprogrammed Cells in Advancing Breast Cancer Research.Cells · 2023Review
- Advances in Rodent Models for Breast Cancer Formation, Progression, and Therapeutic Testing.Frontiers in oncology · 2021Review
- Breast cancer animal models and applications.Zoological research · 2020Review
- Opening large-conductance potassium channels selectively induced cell death of triple-negative breast cancer.BMC cancer · 2020Article
- A Syngeneic ErbB2 Mammary Cancer Model for Preclinical Immunotherapy Trials.Journal of mammary gland biology and neoplasia · 2019Article
- Mouse models of breast cancer in preclinical research.Laboratory animal research · 2018Review
- Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine.Cell death and differentiation · 2018Review
- Making a virtue of necessity: the pleiotropic role of human endogenous retroviruses in cancer.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Advances in the development of improved animal-free models for use in breast cancer biomedical research.Biophysical reviews · 2017Review
- Review
- Endogenous retroviruses and the development of cancer.Journal of immunology (Baltimore, Md. : 1950) · 2014Review
- Pttg1/securin is required for the branching morphogenesis of the mammary gland and suppresses mammary tumorigenesis.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Three interrelated themes in current breast cancer research: gene addiction, phenotypic plasticity, and cancer stem cells.Breast cancer research : BCR · 2011Review
- Choosing a mouse model: experimental biology in context--the utility and limitations of mouse models of breast cancer.Cold Spring Harbor perspectives in biology · 2011Review
- Quantitative assessment of mammary gland density in rodents using digital image analysis.Biological procedures online · 2011Article
- Mammary Cancer Models: An Overview from the Past to the Future.In vivo (Athens, Greece)Review
- Exacerbation of paclitaxel-induced neuropathic pain behaviors in breast tumor-bearing mice.Molecular painArticle
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
For over a century, mouse mammary tumor biology and the associated mouse mammary tumor virus (MMTV) have served as the foundation for experimental cancer research, in general, and, in particular, experimental breast cancer research. Spontaneous mouse mammary tumors were the basis for studies of the natural history of neoplasia, oncogenic viruses, host responses, endocrinology and neoplastic progression. However, lacking formal proof of a human mammary tumor virus, the preeminence of the mouse model faded in the 1980s. Since the late 1980s, genetically engineered mice (GEM) have proven extremely useful for studying breast cancer and have become the animal model for human breast cancer. Hundreds of mouse models of human breast cancer have been developed since the first demonstration in 1984. The GEM have attracted a new generation of molecular and cellular biologists eager to apply their skill sets to these surrogates of the human disease. Newcomers often enter the field without an appreciation of the origins of mouse mammary tumor biology and the basis for many of the prevailing concepts. Our purpose in writing this compendium is to extend an "olive branch" while simultaneously deepen the knowledge of the novice mouse mammary tumor biologist as they journey into a field rich in pathology and genetics spanning several centuries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.