ArticleAmerican journal of epidemiology2010
Why does lung function predict mortality? Results from the Whitehall II Cohort Study.
Article in American journal of epidemiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 71 citations in OpenAlex.
- A randomized controlled trial of vitamin E and selenium on rate of decline in lung function.Respiratory research · 2015Trial
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- Multimodal Ageing Biomarkers and Plasma Proteomic Signatures Associated With All-Cause Mortality.Aging cell · 2026Article
- Short-term exposure to heat associated with lower lung function in older adults: analysis of the Lung VITAL cohort.BMJ open respiratory research · 2026Article
- [Management of patients with chronic obstructive pulmonary disease in routine clinical practice].Innere Medizin (Heidelberg, Germany) · 2026Review
- Pediatric Asthma in the Inland Empire: Environmental Burden, Gaps in Preventive Care, and Unmet Needs.Children (Basel, Switzerland) · 2025Review
- Unlocking the link: predicting cardiovascular disease risk with a focus on airflow obstruction using machine learning.BMC medical informatics and decision making · 2025Article
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- Rapid FEVJournal of Korean medical science · 2023Article
- Spirometry at diagnosis and overall survival in non-small cell lung cancer patients.Cancer medicine · 2022Article
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- Polygenic scores for low lung function and the future risk of adverse health outcomes.Cardiovascular diabetology · 2022Article
- All-cause and cardiovascular mortality in relation to lung function in the full range of distribution across four Eastern European cohorts.Scientific reports · 2022Article
- Impaired lung function and mortality in Eastern Europe: results from multi-centre cohort study.Respiratory research · 2022Article
- Association of lung function with the risk of cardiovascular diseases and all-cause mortality in patients with diabetes: Results from NHANES III 1988-1994.Frontiers in cardiovascular medicine · 2022Article
- Associations between lung function and future cardiovascular morbidity and overall mortality in a predominantly First Nations population: a cohort study.The Lancet regional health. Western Pacific · 2021Article
- Association between lung function and future risks of diabetes, asthma, myocardial infarction, hypertension and all-cause mortality.ERJ open research · 2021Article
- Socioeconomic Inequality in Respiratory Health in the US From 1959 to 2018.JAMA internal medicine · 2021Article
- Association between airflow limitation and prognosis in patients with chronic pulmonary aspergillosis.Journal of thoracic disease · 2021Article
- Association of lung function with overall mortality is independent of inflammatory, cardiac, and functional biomarkers in older adults: the ActiFE-study.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The authors examined the extent to which socioeconomic position, behavior-related factors, cardiovascular risk factors, inflammatory markers, and chronic diseases explain the association between poor lung function and mortality in 4,817 participants (68.9% men) from the Whitehall II Study aged 60.8 years (standard deviation, 5.9), on average. Forced expiratory volume in 1 second (FEV(1)) was used to measure lung function in 2002-2004. A total of 139 participants died during a mean follow-up period of 6.4 years (standard deviation, 0.8). In a model adjusted for age and sex, being in the lowest tertile of FEV(1)/height(2) was associated with a 1.92-fold (95% confidence interval: 1.35, 2.73) increased risk of mortality compared with being in the top 2 tertiles. Once age, sex, and smoking history were taken into account, the most important explanatory factors for this association were inflammatory markers (21.3% reduction in the FEV(1)/height(2)-mortality association), coronary heart disease, stroke, and diabetes (11.7% reduction), and alcohol consumption, diet, physical activity, and body mass index (9.8% reduction). The contribution of socioeconomic position and cardiovascular risk factors was small (≤ 3.5% reduction). Taken together, these factors explained 32.5% of the association. Multiple pathways link lung function to mortality; these results show inflammatory markers to be particularly important.
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Registered trials
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