ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2011
Cystatin C, mortality risk and clinical triage in US adults: threshold values and hierarchical importance.
Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- Association Between Dietary Quality and Serum Cystatin C in Kidney Transplant Recipients Based on Chinese Diet Balance Index 2016 (DBI-16).Annals of transplantation · 2023Article
- Higher Cystatin C Levels Are Associated With Neurocognitive Impairment in Older HIV+ Adults.Journal of acquired immune deficiency syndromes (1999) · 2017Article
- Kidney Function After the First Kidney Stone Event.Mayo Clinic proceedings · 2016Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIt has been suggested that cystatin C may be a superior measure of estimated glomerular filtration rate (eGFR) than creatinine-based methods. We aimed to assess the utility of cystatin C for clinical triage in community-based settings.
methodsWe identified cystatin C thresholds that maximize sensitivity and specificity (Max(Sn + Sp)) for predicting death and subsequently applied classification tree methodology considering serum creatinine, creatinine-based eGFR, urinary albumin-creatinine ratio and conventional modifiable risk factors to define subgroups, interactions and hierarchical ranks in fasting US adults (National Health and Nutrition Examination Survey 1988-94, followed through 2006).
resultsA threshold cystatin C value of 0.94 mg/L exhibited the best maximum combined value of sensitivity and specificity for predicting death (Max(Sn + Sp), Sn 0.64/Sp 0.78). When all variables were considered jointly in a classification tree, cystatin C and albumin-creatinine ratio were the primary mortality discriminators in subgroups that added up to 41 and 14% of the study population, respectively; serum creatinine and creatinine-based eGFR were non-discriminatory.
conclusionCystatin C may be useful for risk-based clinical triage in public health settings.
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Registered trials
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