ArticleTrends in cell biology2011
Autophagy: a broad role in unconventional protein secretion?
Article in Trends in cell biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 74 citations in OpenAlex.
- Plant-Derived Vesicle-like Nanoparticles for Cancer Therapy: From Drug Delivery to Combined Immunotherapy.Antioxidants (Basel, Switzerland) · 2026Review
- Epigenetic Regulation of Autophagy in Bone Metabolism.Function (Oxford, England) · 2024Review
- A kaleidoscopic view of extracellular vesicles in lysosomal storage disorders.Extracellular vesicles and circulating nucleic acids · 2022Review
- Early Bioinformatic Implication of Triacidic Amino Acid Motifs in Autophagy-Dependent Unconventional Secretion of Mammalian Proteins.Frontiers in cell and developmental biology · 2022Article
- Acid Sphingomyelinase Deficiency: A Clinical and Immunological Perspective.International journal of molecular sciences · 2021Review
- Article
- Oxidative stress-induced RAC autophagy can improve the HUVEC functions by releasing exosomes.Journal of cellular physiology · 2020Article
- The GABARAP Co-Secretome Identified by APEX2-GABARAP Proximity Labelling of Extracellular Vesicles.Cells · 2020Article
- Facets of Autophagy Based Unconventional Protein Secretion-The Road Less Traveled.Frontiers in molecular biosciences · 2020Review
- N-terminal β-strand underpins biochemical specialization of an ATG8 isoform.PLoS biology · 2019Article
- A New Look at the Functional Organization of the Golgi Ribbon.Frontiers in cell and developmental biology · 2019Article
- Ischemic Conditions Affect Rerouting of Tau Protein Levels: Evidences for Alteration in Tau Processing and Secretion in Hippocampal Neurons.Journal of molecular neuroscience : MN · 2018Article
- Temporal analysis of the autophagic and apoptotic phenotypes inMicrobial cell (Graz, Austria) · 2018Article
- The E3 ubiquitin ligase NEDD4 mediates cell migration signaling of EGFR in lung cancer cells.Molecular cancer · 2018Article
- Cell viability assessed in a reproducible model of human osteoblasts derived from human adipose-derived stem cells.PloS one · 2018Article
- Clinical Applications of Autophagy Proteins in Cancer: From Potential Targets to Biomarkers.International journal of molecular sciences · 2017Review
- Prelysosomal Compartments in the Unconventional Secretion of Amyloidogenic Seeds.International journal of molecular sciences · 2017Review
- Article
- The effect of tetrandrine combined with cisplatin on proliferation and apoptosis of A549/DDP cells and A549 cells.Cancer cell international · 2017Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Autophagy, a cellular 'self-eating' process in eukaryotic cells, exists in both a basal and in an activated state that is induced in response to starvation. Basal and induced autophagy are associated with the packaging of cellular components, including damaged and/or redundant organelles, into double-membrane vesicles called autophagosomes, followed by autophagosome fusion with lysosomes, in which their contents are degraded and recycled. Recent results highlight a novel role for autophagy that does not involve lysosomal degradation of autophagosomal contents, but instead involves their redirection towards the extracellular delivery of an unconventionally secreted protein. Here, we discuss these findings, evaluate the strength of evidence, consider their implications for the field of protein trafficking, and suggest the next steps required to probe this interesting pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.