Evidence map›Paper›PMID 20961303›Full record

ArticleAnnals of the New York Academy of Sciences2010

Microanatomy of the intestinal lymphatic system.

Mark J Miller, Jeremiah R McDole, Rodney D Newberry

Open access · greenAbstract read
In one paragraph

Article in Annals of the New York Academy of Sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Hypercholesterolemia-induced LXR signaling in smooth muscle cells contributes to vascular lesion remodeling and visceral function.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Review
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  11. Review
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  15. Colonic Intramural Hematoma in a Cat: A Case Report.Frontiers in veterinary science · 2022
    Article
  16. Article
  17. Review
  18. Review
  19. An update on oral drug deliveryActa pharmaceutica Sinica. B · 2021
    Review
  20. Ethanol-induced lymphatic endothelial cell permeability via MAP-kinase regulation.American journal of physiology. Cell physiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Mark J MillerDepartment of Pathology and Immunology, St. Louis, Missouri, USA.
Jeremiah R McDole
Rodney D Newberry
University of Missouri–St. Louis · USWashington University in St. Louis · US

Funding

Epithelial Responses to Bacterial InvasionR01AI077600 · NIAID · WASHINGTON UNIVERSITY · PI MILLER, MARK JAMES · 2009 to 2021
$3.8M
Lymphotoxin Beta Receptor in Intestinal InflammationR01DK064798 · NIDDK · WASHINGTON UNIVERSITY · PI NEWBERRY, RODNEY D · 2005 to 2013
$2.8M
Epithelia Associated Dendritic Cells: Phenotype and FunctionR21AI083538 · NIAID · WASHINGTON UNIVERSITY · PI NEWBERRY, RODNEY D · 2009 to 2010
$415k
NIAID NIH HHS AI077600NIAID NIH HHS AI083538NIAID NIH HHS R01 AI077600NIAID NIH HHS R21 AI083538NIDDK NIH HHS DK64798NIDDK NIH HHS R01 DK064798
6 · The paper itself

Abstract

The intestinal lymphatic system comprises two noncommunicating lymphatic networks: one containing the lacteals draining the villi and the connecting submucosal lymphatic network and one containing the lymphatics that drain the intestine muscular layer. These systems deliver lymph into a common network of collecting lymphatics originating near the mesenteric border. The intestinal lymphatic system serves vital functions in the regulation of tissue fluid homeostasis, immune surveillance, and the transport of nutrients; conversely, this system is affected by, and directly contributes to, disease processes within the intestine. Recent discoveries of specific lymphatic markers, factors promoting lymphangiogenesis, and factors selectively affecting the development of intestinal lymphatics, hold promise for unlocking the role of lymphatics in the pathogenesis of diseases affecting the intestine and for intestinal lymphatic selective therapies. Vital to progress in understanding how the intestinal lymphatic system functions is the integration of recent advances identifying molecular pathways for lymphatic growth and remodeling with advanced imaging modalities to observe lymphatic function and dysfunction in vivo.

Indexed as

HumansIntestinesLymphatic SystemMicroscopy

Identifiers

PMID20961303
PMCPMC3064563
OpenAlexW1900765734

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.