ArticleAIDS research and human retroviruses2011
Pulmonary vascular lesions are common in SIV- and SHIV-env-infected macaques.
Article in AIDS research and human retroviruses, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- The Latest in Animal Models of Pulmonary Hypertension and Right Ventricular Failure.Circulation research · 2022Review
- Review
- Mice with humanized immune system as novel models to study HIV-associated pulmonary hypertension.Frontiers in immunology · 2022Article
- Impact of human immunodeficiency virus on pulmonary vascular disease.Global cardiology science & practice · 2021Review
- International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and Proliferative Lesions of the Non-human Primate (Journal of toxicologic pathology · 2021Review
- Statin treatment prevents the development of pulmonary arterial hypertension in a nonhuman primate model of HIV-associated PAH.Scientific reports · 2019Article
- Monocyte and Alveolar Macrophage Skewing Is Associated with the Development of Pulmonary Arterial Hypertension in a Primate Model of HIV Infection.AIDS research and human retroviruses · 2019Article
- Longitudinal Evaluation of Pulmonary Arterial Hypertension in a Rhesus Macaque (Comparative medicine · 2018Article
- Drug abuse and HIV-related pulmonary hypertension: double hit injury.AIDS (London, England) · 2018Review
- Lung Vascular Remodeling, Cardiac Hypertrophy, and Inflammatory Cytokines in SHIVnef-Infected Macaques.Viral immunology · 2018Article
- Effect of Cocaine on Pulmonary Vascular Remodeling and Hemodynamics in Human Immunodeficiency Virus-Transgenic Rats.American journal of respiratory cell and molecular biology · 2016Article
- Massive occlusive thrombosis of the pulmonary artery in pigtailed macaques chronically infected with R5-tropic simian-human immunodeficiency virus.Journal of medical primatology · 2015Article
- Pathogenesis of HIV and the lung.Current HIV/AIDS reports · 2013Review
- Physiologic changes in a nonhuman primate model of HIV-associated pulmonary arterial hypertension.American journal of respiratory cell and molecular biology · 2013Article
- Article
- Human Immunodeficiency Virus nef signature sequences are associated with pulmonary hypertension.AIDS research and human retroviruses · 2012Article
- Injection drug use as a "second hit" in the pathogenesis of HIV-associated pulmonary hypertension.American journal of respiratory and critical care medicine · 2012Article
- Enhanced pulmonary arteriopathy in simian immunodeficiency virus-infected macaques exposed to morphine.American journal of respiratory and critical care medicine · 2012Article
- Pneumocystis infection and the pathogenesis of chronic obstructive pulmonary disease.Immunologic research · 2011Article
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Authors and funding
11 authors.
Funding
Abstract
The lack of animal models of HIV-related pulmonary arterial hypertension (HIV-PAH) severely limits investigation of this serious disease. While histological evidence of HIV-PAH has been demonstrated in macaques infected with simian immunodeficiency virus (SIV) as well as with chimeric simian/human immunodeficiency virus (SHIV) containing HIV-1-derived Nef protein, other primate models have not been studied. The objective was to document and describe the development of pulmonary vascular changes in macaques infected with SIV or with SIV containing HIV-1-derived envelope protein (SHIV-env). Lung tissue was obtained at necropsy from 13 SHIV (89.6P)-env-infected macaques and 10 SIV (ΔB670)-infected macaques. Pulmonary arterial pathology, including arterial hyperplasia and the presence of plexiform lesions, was compared to normal monkey lung. Pulmonary artery hyperplasia was present in 8 of 13 (62%) SHIV-env-infected macaques and 4/10 (36%) SIV-infected macaques. The most common histopathological lesions were intimal and medial hyperplasia of medium and large pulmonary arteries. Hyperplastic lesions were predominantly due to smooth muscle cell hyperplasia. This is the first report of pulmonary vascular lesions in SHIV-env-infected macaques and confirms prior reports of pulmonary vasculopathy in SIV-infected macaques. The finding of pulmonary arteriopathy in monkeys infected with SHIV not containing HIV-nef suggests that other factors might also be important in the development of HIV-PAH. This SHIV-env model provides a new means to investigate HIV-PAH.
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