ArticleBrain injury2010
APOE genetic associations with seizure development after severe traumatic brain injury.
Article in Brain injury, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Apolipoprotein E4 Polymorphism and Outcomes from Traumatic Brain Injury: A Living Systematic Review and Meta-Analysis.Journal of neurotrauma · 2021Pooled it
- Genetic variability in glutamic acid decarboxylase genes: associations with post-traumatic seizures after severe TBI.Epilepsy research · 2013Trial
- Post-Traumatic Epilepsy and Comorbidities: Advanced Models, Molecular Mechanisms, Biomarkers, and Novel Therapeutic Interventions.Pharmacological reviews · 2022Review
- The pharmacogenomics of severe traumatic brain injury.Pharmacogenomics · 2017Review
- Traumatic brain injury history is associated with earlier age of onset of Alzheimer disease.The Clinical neuropsychologist · 2017Article
- Review
- Epileptogenesis.Cold Spring Harbor perspectives in medicine · 2015Review
- A Rehabilomics framework for personalized and translational rehabilitation research and care for individuals with disabilities: Perspectives and considerations for spinal cord injury.The journal of spinal cord medicine · 2014Article
- Epilepsy related to traumatic brain injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2014Review
- Apolipoprotein epsilon 3 alleles are associated with indicators of neuronal resilience.BMC medicine · 2012Article
- Genetics and outcomes after traumatic brain injury (TBI): what do we know about pediatric TBI?Journal of pediatric rehabilitation medicine · 2012Review
- Genetic Contributions to Acquired Epilepsies.Epilepsy currentsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
PRIMARY
objectiveThe purpose of the current study is to assess the role of the APOE genotype in post-traumatic seizure (PTS) development. RESEARCH
designA retrospective study of 322 adult Caucasians with a severe TBI and APOE genotype. METHODS AND PROCEDURES: Medical records were searched for PTS. Time to first seizure was categorized as early, late or delayed-onset PTS. Potential PTS associations by genotype, grouped genotype and allele were investigated. MAIN OUTCOME AND
resultsNo statistically significant associations were found. However, two out of the four individuals (50%) with the E4/E4 genotype had late/delayed-onset PTS. Furthermore, none with a E2/E2 or E2/E4 genotype seized in the late periods.
conclusionsThe results of this study may suggest 4/4 as a risk genotype for late/delayed onset PTS and a potential neuroprotective role of the E2 allele. However, this study did not definitively support a role for the APOE genotype in PTS susceptibility and indicates that larger populations are needed to fully evaluate the potential impact of APOE on PTS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.