ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2010
Lack of motor neuron differentiation is an intrinsic property of the mouse secondary neural tube.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Caudal Fgfr1 disruption produces localised spinal mis-patterning and a terminal myelocystocele-like phenotype in mice.Development (Cambridge, England) · 2023Article
- Embryonal Neuromesodermal Progenitors for Caudal Central Nervous System and Tissue Development.Journal of Korean Neurosurgical Society · 2021Article
- Lineage tracing of axial progenitors using Nkx1-2CreERDevelopment (Cambridge, England) · 2018Article
- Junctional neurulation: a unique developmental program shaping a discrete region of the spinal cord highly susceptible to neural tube defects.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- β-catenin regulates Pax3 and Cdx2 for caudal neural tube closure and elongation.Development (Cambridge, England) · 2014Article
- Secondary neurulation of human embryos: morphological changes and the expression of neuronal antigens.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2014Article
- Distribution and characterization of progenitor cells within the human filum terminale.PloS one · 2011Article
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4 authors.
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Abstract
The cranial part of the amniote neural tube is formed by folding and fusion of the ectoderm-derived neural plate (primary neurulation). After posterior neuropore closure, however, the caudal neural tube is formed by cavitation of tail bud mesenchyme (secondary neurulation). In mouse embryos, the secondary neural tube expresses several genes important in early patterning and induction, in restricted domains similar to the primary neural tube, yet it does not undergo neuronal differentiation, but subsequently degenerates. Although the secondary neural tube, isolated from surrounding tissues, is responsive to exogenous Sonic Hedgehog proteins in vitro, motor neuron differentiation is never observed. This cannot be attributed to the properties of the secondary notochord, since it is able to induce motor neuron differentiation in naive chick neural plate explants. Taken together, these results support that the lack of motor neuron differentiation is an intrinsic property of the mouse secondary neural tube.
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