Evidence map›Paper›PMID 20960298›Full record

ReviewVirologica Sinica2010

Hepatitis C virus experimental model systems and antiviral drug research.

Susan L Uprichard

Abstract readReview
In one paragraph

Review in Virologica Sinica, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Susan L UprichardDepartment of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA. sluprich@uic.edu

Funding

High Throughput in vitro Hepatitis C Virus ScreeningR01AI070827 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI UPRICHARD, SUSAN L. · 2006 to 2009
$887k
Development of 3D Differentiated Hepatocyte Culture Systems for the Study of HCCR21CA133266 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI UPRICHARD, SUSAN L. · 2008 to 2009
$377k
NCI NIH HHS CA33266NCI NIH HHS R21 CA133266NIAID NIH HHS AI070827NIAID NIH HHS R01 AI070827
6 · The paper itself

Abstract

An estimated 130 million people worldwide are chronically infected with hepatitis C virus (HCV) making it a leading cause of liver disease worldwide. Because the currently available therapy of pegylated interferon-alpha and ribavirin is only effective in a subset of patients, the development of new HCV antivirals is a healthcare imperative. This review discusses the experimental models available for HCV antiviral drug research, recent advances in HCV antiviral drug development, as well as active research being pursued to facilitate development of new HCV-specific therapeutics.

Indexed as

AnimalsAntiviral AgentsDisease Models, AnimalDrug Evaluation, PreclinicalHepacivirusHepatitis C, ChronicHumansMicrobial Sensitivity TestsAntiviral Agents

Identifiers

PMID20960298
PMCPMC2963037

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.