Evidence map›Paper›PMID 20960269›Full record

ArticleEndocrine2010

Epithelial progenitor 1, a novel factor associated with epithelial cell growth and differentiation.

Marcie R Kritzik, Cory U Lago, Ayse G Kayali, Sandrine Arnaud-Dabernat, Guoxun Liu, You-Qing Zhang, Hong Hua, Howard S Fox, Nora E Sarvetnick

Open access · greenAbstract read
In one paragraph

Article in Endocrine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Marcie R KritzikDepartment of Immunology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Cory U Lago
Ayse G Kayali
Sandrine Arnaud-Dabernat
Guoxun Liu
You-Qing Zhang
Hong Hua
Howard S Fox
Nora E Sarvetnick
Scripps Research Institute · USUniversity of Nebraska Medical Center · USUniversity of California, San Diego · US

Funding

Purification &Characterization of Islet ProgenitorsR01DK060746 · NIDDK · SCRIPPS RESEARCH INSTITUTE, THE · PI SARVETNICK, NORA E · 2003 to 2007
$2.0M
Methamphetamine/SIV Interaction in the CNSR01DA024467 · NIDA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI FOX, HOWARD S · 2007 to 2010
$1.4M
Engraftment of Pancreatic ProgenitorsR21DK066511 · NIDDK · SCRIPPS RESEARCH INSTITUTE · PI SARVETNICK, NORA E · 2003 to 2004
$751k
HEMODYNAMICS IN IN VITRO AND IN VIVO INJURED LIVERK08HL000795 · NHLBI · UNIVERSITY OF IOWA · PI BROWN, BRUCE P · 1985 to 1985
–
NHLBI NIH HHS T32 HL00795NIDA NIH HHS R01 DA024467NIDDK NIH HHS DK 60746NIDDK NIH HHS R01 DK060746NIDDK NIH HHS R21 DK066511
6 · The paper itself

Abstract

The growth and renewal of epithelial tissue is a highly orchestrated and tightly regulated process occurring in different tissue types under a variety of circumstances. We have been studying the process of pancreatic regeneration in mice. We have identified a cell surface protein, named EP1, which is expressed on the duct epithelium during pancreatic regeneration. Whereas it is not detected in the pancreas of normal mice, it is found in the intestinal epithelium of normal adult mice, as well as during pancreatic repair following cerulein-induced destruction of the acinar tissue. The distinctive situations in which EP1 is expressed, all of which share in common epithelial cell growth in the gastrointestinal tract, suggest that EP1 is involved in the growth and renewal of epithelial tissues in both the intestine and the pancreas.

Indexed as

Amino Acid SequenceAnimalsCell DifferentiationChemokine CXCL12Epithelial CellsIntestinesMembrane ProteinsMiceMice, Inbred C57BLMice, Inbred NODMice, SCIDMice, TransgenicMitosisMolecular Sequence DataPancreasReceptors, CXCR4Chemokine CXCL12Cxcl12 protein, mouseCXCR4 protein, mouseepithelial progenitor 1 protein, mouseMembrane ProteinsReceptors, CXCR4

Identifiers

PMID20960269
PMCPMC4288843
OpenAlexW1977679966

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.