ArticleMolecular imaging and biology2011
Where it's at really matters: in situ in vivo vascular endothelial growth factor spatially correlates with electron paramagnetic resonance pO2 images in tumors of living mice.
Article in Molecular imaging and biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Nondestructive, longitudinal, 3D oxygen imaging of cells in a multi-well plate using pulse electron paramagnetic resonance imaging.Npj imaging · 2024Article
- In vitro oxygen imaging of acellular and cell-loaded beta cell replacement devices.Scientific reports · 2023Article
- Absolute oxygen-guided radiation therapy improves tumor control in three preclinical tumor models.Frontiers in medicine · 2023Article
- Biological validation of electron paramagnetic resonance (EPR) image oxygen thresholds in tissue.The Journal of physiology · 2021Review
- Going Low in a World Going High: The Physiologic Use of Lower Frequency Electron Paramagnetic Resonance.Applied magnetic resonance · 2020Article
- Effects of Photodynamic Therapy with Redaporfin on Tumor Oxygenation and Blood Flow in a Lung Cancer Mouse Model.Scientific reports · 2019Article
- Merging Preclinical EPR Tomography with other Imaging Techniques.Cell biochemistry and biophysics · 2019Article
- Oxygen-Guided Radiation Therapy.International journal of radiation oncology, biology, physics · 2019Article
- Highly sensitive electron paramagnetic resonance nanoradicals for quantitative intracellular tumor oxymetric images.International journal of nanomedicine · 2019Article
- In vivo preclinical cancer and tissue engineering applications of absolute oxygen imaging using pulse EPR.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2017Review
- Triarylmethyl Radicals: EPR Study ofZeitschrift fur physikalische Chemie (Frankfurt am Main, Germany) · 2017Article
- Imaging thiol redox status in murine tumors in vivo with rapid-scan electron paramagnetic resonance.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2017Article
- Fast dynamic electron paramagnetic resonance (EPR) oxygen imaging using low-rank tensors.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2016Article
- Facile and High-Yielding Synthesis of TAM Biradicals and Monofunctional TAM Radicals.Synlett : accounts and rapid communications in synthetic organic chemistry · 2016Article
- In Vivo pO2 Imaging of Tumors: Oxymetry with Very Low-Frequency Electron Paramagnetic Resonance.Methods in enzymology · 2015Review
- Absolute oxygen R1e imaging in vivo with pulse electron paramagnetic resonance.Magnetic resonance in medicine · 2014Article
- New spectral-spatial imaging algorithm for full EPR spectra of multiline nitroxides and pH sensitive trityl radicals.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2014Article
- Principal component analysis enhances SNR for dynamic electron paramagnetic resonance oxygen imaging of cycling hypoxia in vivo.Magnetic resonance in medicine · 2014Article
- Preparation of Diversely Substituted Triarylmethyl Radicals by the Quenching of Tris(2,3,5,6-tetrathiaaryl)methyl Cations with C-, N-, P-, and S-Nucleophiles.European journal of organic chemistry · 2014Article
- Radiation oxygen biology with pulse electron paramagnetic resonance imaging in animal tumors.Advances in experimental medicine and biology · 2013Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
purposeTumor microenvironments show remarkable tumor pO(2) heterogeneity, as seen in prior EPR pO(2) images (EPROI). pO(2) correlation with hypoxia response proteins is frustrated by large rapid pO(2) changes with position. PROCEDURES: To overcome this limitation, biopsies stereotactically located in the EPROI were used to explore the relationship between vascular endothelial growth factor A (VEGF) concentrations in living mouse tumors and the local EPROI pO(2).
resultsQuantitative ELISA VEGF concentrations correlated (p = 0.0068 to 0.019) with mean pO(2), median pO(2), and the fraction of voxels in the biopsy volume with pO(2) less than 3, 6, and 10 Torr.
conclusionsThis validates EPROI hypoxic fractions at the molecular level and provides a new paradigm for the assessment of the relationship, in vivo, between hypoxia and hypoxia response proteins. When translated to human subjects, this will enhance understanding of human tumor pathophysiology and cancer response to therapy.
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