ArticleMolecular and cellular biochemistry2011
High glucose promotes cell proliferation and enhances GDNF and RET expression in pancreatic cancer cells.
Article in Molecular and cellular biochemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 63 citations in OpenAlex.
- Impact of metformin use on the recurrence of hepatocellular carcinoma after initial liver resection in diabetic patients.PloS one · 2021Trial
- Pancreatic endocrine and exocrine signaling and crosstalk in physiological and pathological status.Signal transduction and targeted therapy · 2025Review
- Pancreatic cancer mortality trends attributable to high fasting blood sugar over the period 1990-2019 and projections up to 2040.Frontiers in endocrinology · 2024Article
- GDNF regulates lipid metabolism and glioma growth through RET/ERK/HIF‑1/SREBP‑1.International journal of oncology · 2022Article
- The Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRα) in Cancers.International journal of medical sciences · 2022Review
- Epidemiological link between obesity, type 2 diabetes mellitus and cancer.World journal of methodology · 2021Review
- Beneficial Diets and Pancreatic Cancer: Molecular Mechanisms and Clinical Practice.Frontiers in oncology · 2021Review
- NF-κB and STAT3 co-operation enhances high glucose induced aggressiveness of cholangiocarcinoma cells.Life sciences · 2020Article
- The Impact of obesity and diabetes mellitus on pancreatic cancer: Molecular mechanisms and clinical perspectives.Journal of cellular and molecular medicine · 2020Review
- Synergistic Association of Carcinoembryonic Antigen and Carbohydrate Antigen 19-9 on the Risk of Abnormal Glucose Regulation.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- The Impact of Serum Glucose in the Treatment of Locoregionally Advanced Pancreatic Cancer.American journal of clinical oncology · 2019Article
- High glucose microenvironment accelerates tumor growth via SREBP1-autophagy axis in pancreatic cancer.Journal of experimental & clinical cancer research : CR · 2019Article
- High glucose promotes pancreatic cancer cells to escape from immune surveillance via AMPK-Bmi1-GATA2-MICA/B pathway.Journal of experimental & clinical cancer research : CR · 2019Article
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- Silencing Tspan1 inhibits migration and invasion, and induces the apoptosis of human pancreatic cancer cells.Molecular medicine reports · 2018Article
- Application of a novel targeting nanoparticle contrast agent combined with magnetic resonance imaging in the diagnosis of intraductal papillary mucinous neoplasm.Experimental and therapeutic medicine · 2018Article
- Macrophage Cytokines Enhance Cell Proliferation of Normal Prostate Epithelial Cells through Activation of ERK and Akt.Scientific reports · 2018Article
- The GDNF Family: A Role in Cancer?Neoplasia (New York, N.Y.) · 2018Review
- Hyperglycemia aggravates microenvironment hypoxia and promotes the metastatic ability of pancreatic cancer.Computational and structural biotechnology journal · 2018Article
- High glucose levels promote the proliferation of breast cancer cells through GTPases.Breast cancer (Dove Medical Press) · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperglycemia promotes pancreatic cancer progression, while the underlying mechanism is uncertain. We investigated the cell proliferation, glial cell line-derived neurotrophic factor (GDNF) and its tyrosine kinase receptor RET expression in BxPC-3 and MIA PaCa-2 cells when exposed to different concentrations of glucose. Proliferation of both cells was effected by glucose in a concentration-dependent manner. Definite expression of GDNF and RET was detected in both cells. Glucose concentrations could alter the expression of GDNF and RET in a concentration-dependent manner, correspondingly with the alterations of cell proliferation. Up-regulation of GDNF and RET ligand-receptor interaction might participate in the glucose-induced cancer progression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.