ArticlePsychopharmacology2011
Behavioral characterization of adult male and female rhesus monkeys exposed to cocaine throughout gestation.
Article in Psychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed.
- Delay discounting as a behavioral phenotype associated with social rank in female and male cynomolgus monkeys: Correlation with kappa opioid receptor availability.Pharmacology, biochemistry, and behavior · 2023Article
- Mass Spectrometry-Based Proteome Profiling of Extracellular Vesicles Derived from the Cerebrospinal Fluid of Adult Rhesus Monkeys Exposed to Cocaine throughout Gestation.Biomolecules · 2022Article
- Sex differences in animal models of decision making.Journal of neuroscience research · 2017Review
- Cocaine-induced neurodevelopmental deficits and underlying mechanisms.Birth defects research. Part C, Embryo today : reviews · 2016Review
- Evaluation of the Reinforcing Effect of Quetiapine, Alone and in Combination with Cocaine, in Rhesus Monkeys.The Journal of pharmacology and experimental therapeutics · 2016Article
- Animal models for addiction medicine: From vulnerable phenotypes to addicted individuals.Progress in brain research · 2016Review
- Effects of quetiapine treatment on cocaine self-administration and behavioral indices of sleep in adult rhesus monkeys.Psychopharmacology · 2015Article
- Recent Insights into the Neurobiology of Impulsivity.Current addiction reports · 2014Article
- Developmental origins of brain disorders: roles for dopamine.Frontiers in cellular neuroscience · 2013Review
- The relationship between cocaine self-administration and actigraphy-based measures of sleep in adult rhesus monkeys.Psychopharmacology · 2013Article
- Delayed developmental changes in neonatal vocalizations correlates with variations in ventral medial hypothalamus and central amygdala development in the rodent infant: effects of prenatal cocaine.Behavioural brain research · 2012Article
- Impulsivity and drugs of abuse: a juice-reinforced operant procedure for determining within-session delay discounting functions in rhesus monkeys.Journal of pharmacological and toxicological methodsArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
rationaleIn utero cocaine exposure has been associated with alterations in the dopamine (DA) system in monkeys. However, the behavioral outcomes of prenatal cocaine exposure in adulthood are poorly understood.
objectivesTo assess several behavioral measures in 14-year-old rhesus monkeys exposed to cocaine in utero and controls (n = 10 per group). MATERIALS AND
methodsFor these studies, two unconditioned behavioral tasks, novel object reactivity and locomotor activity, and two conditioned behavioral tasks, response extinction and delay discounting, were examined. In addition, cerebrospinal fluid (CSF) samples were analyzed for concentrations of the monoamine metabolites homovanillic acid (HVA) and 5-hydroxyindole acetic acid (5-HIAA).
resultsNo differences in CSF concentrations of 5-HIAA and HVA, latencies to touch a novel object or locomotor activity measures were observed between groups or sexes. However, prenatally cocaine-exposed monkeys required a significantly greater number of sessions to reach criteria for extinction of food-reinforced behavior than control monkeys. On the delay-discounting task, male prenatally cocaine-exposed monkeys switched preference from the larger reinforcer to the smaller one at shorter delay values than male control monkeys; no differences were observed in females.
conclusionsThese findings suggest that prenatal cocaine exposure results in long-term neurobehavioral deficits that are influenced by sex of the individual.
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