Evidence map›Paper›PMID 20959867›Full record

ArticleJournal of addiction medicine2010

A Clinical Trial Comparing Tapering Doses of Buprenorphine with Steady Doses for Chronic Pain and Co-existent Opioid Addiction.

Richard D Blondell, Lisham Ashrafioun, Christina M Dambra, Elisa M Foschio, Amy L Zielinski, Daniel M Salcedo

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of addiction medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00552578 (A Randomized Controlled Trial Testing Buprenorphine as a Treatment in Opiate Dependent Pain Patients), which is not on this map. Cited by 29 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 7 pooled it
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00552578 phase4terminatednot on this map

A Randomized Controlled Trial Testing Buprenorphine as a Treatment in Opiate Dependent Pain Patients

TypeinterventionalSponsorState University of New York at BuffaloRan2007 to 2008Enrolled12ConditionsOpiate Addiction, Refractory PainArmsbuprenorphine/naloxone
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 7 syntheses or guidelines pooled it, 61 citations in OpenAlex.

  1. Pooled it
  2. CDC Clinical Practice Guideline for Prescribing Opioids for Pain - United States, 2022.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2022
    Guideline
  3. Pooled it
  4. Pooled it
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  6. Pooled it
  7. Pooled it
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Review
  13. Observational
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Opioids and Chronic Pain: Where Is the Balance?Current oncology reports · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Richard D BlondellDepartment of Family Medicine and the Department of Rehabilitation Medicine, The State University of New York at Buffalo and the Erie County Medical Center Buffalo, New York.
Lisham Ashrafioun
Christina M Dambra
Elisa M Foschio
Amy L Zielinski
Daniel M Salcedo
Buffalo BioLabs · US

Funding

Facilitating Aftercare for Alcohol Detox PatientsK23AA015616 · NIAAA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI BLONDELL, RICHARD D · 2005 to 2009
$1.3M
NIAAA NIH HHS K23 AA015616
6 · The paper itself

Abstract

objectivesEffective strategies are needed to manage individuals with chronic non-cancer pain and coexistent opioid addiction. This study compared opioid discontinuation and opioid replacement protocols.

methodsWe planned to enroll 60 individuals into an open-label trial who had been treated with opioids for chronic non-cancer pain, and who also had opioid addiction. Participants were randomly assigned to one of two 6-month treatment protocols of buprenorphine/naloxone sublingual tablets: 1) tapering doses for opioid weaning or "detoxification" (active comparator group) or 2) steady doses for opioid replacement (experimental group). They were followed monthly for the study outcomes: completion of the 6-month treatment protocol and self-reported pain control, physical functioning, alcohol consumption and illicit drug use.

resultsEnrollment was terminated after enrolling 12 participants because none of the 6 assigned to receive tapering doses could successfully complete the protocol (5 were given steady doses and 1 was admitted to an inpatient chemical dependency treatment program); whereas, of the 6 assigned to receive steady doses, 5 completed the protocol (1 withdrew). This difference between the 2 treatment conditions was significant (P = 0.015). Of the 10 participants who completed the 6 month follow-up, 8 reported improved pain control and physical functioning and 5 used alcohol and/or illicit drugs.

conclusionsWe conclude that over 6 months, these participants with chronic pain and co-existent opioid addiction were more likely to adhere to an opioid replacement protocol than an opioid weaning protocol and that opioid replacement therapy with steady doses of buprenorphine/naloxone is associated with improved pain control and physical functioning.

Indexed as

addictionbuprenorphineDetoxificationopioidspain

Identifiers

PMID20959867
PMCPMC2931595
OpenAlexW2052838856

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.