ReviewPhysiological reviews2010
Intrinsically photosensitive retinal ganglion cells.
Review in Physiological reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03758768 (The Effects of a Blue Monochromatic Light Intervention on Evening-type Individuals' Sleep and Circadian Rhythms), which is not on this map. Cited by 212 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of a Blue Monochromatic Light Intervention on Evening-type Individuals' Sleep and Circadian Rhythms
Who cites it
212 citing papers in PubMed, 1 synthesis or guideline pooled it, 458 citations in OpenAlex.
- Quality of life in non-functioning pituitary adenoma: A systematic review.Neurosurgical review · 2024Pooled it
- Bioinformatic Analysis and Tissue-Specific Expression of Clock Genes andAnimals : an open access journal from MDPI · 2026Article
- Beyond SWS1 Cones: Canonical and Noncanonical Routes of Ultraviolet Sensitivity in the Avian Retina.Birds (Basel, Switzerland) · 2026Article
- The Dark Side of Light: Spectral Variation in Post-Traumatic Photosensitivity and Its Functional Sequelae.Brain sciences · 2026Article
- The Diverse Role of ipRGCs in Visual Perception Beyond Non-Image-Forming Functions.The European journal of neuroscience · 2026Review
- Light Exposure Rhythms and Sleep Organization in Adolescents: Temporal Differences Between Weekdays and Weekends in an Actigraphic Study.Clocks & sleep · 2026Article
- A hypothetical circadian‒endocrine pathway linking melanopsin-expressing ipRGC dysfunction in autoimmune retinopathy to sexual dysfunction.International ophthalmology · 2026Review
- Overexpression or Activation of Potassium Channel TASK-3 Protects Retinal Ganglion Cells and Restores Visual Function in Optic Nerve Crush.Investigative ophthalmology & visual science · 2026Article
- Bright Light Therapy in Psychiatric Disorders: Mechanisms, Clinical Procedures and Evidence.Life (Basel, Switzerland) · 2026Review
- Article
- Retinol tracing within murine neural retina reveals cell type-specific retinol transport and distribution.The Journal of clinical investigation · 2026Article
- Article
- The role of circadian rhythms in the pathogenesis of myopia.Frontiers in physiology · 2026Review
- Seasonal and geographic patterns of gastroschisis in Canada: protective effect of periconceptional sunlight exposure.Frontiers in endocrinology · 2026Article
- An Overview of the Therapeutic Applications of Tinted Lenses Spectacles.Korean journal of ophthalmology : KJO · 2025Review
- Non-visual light modulates behavioral memory and gene expression inbioRxiv : the preprint server for biology · 2025Article
- How to Deal With Darkness: Modeling and Visualization of Zero-Inflated Personal Light Exposure Data on a Logarithmic Scale.Journal of biological rhythms · 2025Article
- Article
- Prenatal alcohol exposure dysregulates the expression of clock genes and alters rhythmic behaviour in mice.Open biology · 2025Article
- Comparative assessment of sleep quality in glaucoma and cataract patients: the need for developing appropriate treatment methods for chronodisruption.International ophthalmology · 2025Article
152 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Life on earth is subject to alternating cycles of day and night imposed by the rotation of the earth. Consequently, living things have evolved photodetective systems to synchronize their physiology and behavior with the external light-dark cycle. This form of photodetection is unlike the familiar "image vision," in that the basic information is light or darkness over time, independent of spatial patterns. "Nonimage" vision is probably far more ancient than image vision and is widespread in living species. For mammals, it has long been assumed that the photoreceptors for nonimage vision are also the textbook rods and cones. However, recent years have witnessed the discovery of a small population of retinal ganglion cells in the mammalian eye that express a unique visual pigment called melanopsin. These ganglion cells are intrinsically photosensitive and drive a variety of nonimage visual functions. In addition to being photoreceptors themselves, they also constitute the major conduit for rod and cone signals to the brain for nonimage visual functions such as circadian photoentrainment and the pupillary light reflex. Here we review what is known about these novel mammalian photoreceptors.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.