SynthesisCephalalgia : an international journal of headache2010
Sex hormone receptor gene polymorphisms and migraine: a systematic review and meta-analysis.
Synthesis in Cephalalgia : an international journal of headache, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03786393 (Investigation of Estrogen Receptor 1 Gene Polymorphism Frequency in Patients With Fibromyalgia Syndrome), which is not on this map. Cited by 28 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigation of Estrogen Receptor 1 Gene Polymorphism Frequency in Patients With Fibromyalgia Syndrome
Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Association of ESR1 Polymorphisms with Susceptibility to Migraine: A Meta-Analysis and Trial Sequential Analysis.Current pain and headache reports · 2025Pooled it
- Genetic variants in migraine: a field synopsis and systematic re-analysis of meta-analyses.The journal of headache and pain · 2020Pooled it
- Pooled it
- Association between estrogen receptor alpha c.454-397T>C and c.454-351A>G and ischemic stroke risk: a systematic review and meta-analysis.Molecular biology reports · 2012Pooled it
- Progesterone Receptor Activation Regulates Sensory Sensitivity and Migraine Susceptibility.The journal of pain · 2024Article
- Menstrual migraine is caused by estrogen withdrawal: revisiting the evidence.The journal of headache and pain · 2023Review
- The Role of Female Reproductive Hormones in the Association between Migraine and Breast Cancer: An Unanswered Question.Biomedicines · 2023Review
- Effect of estrous cycle phases on gene expression in bovine oviduct epithelial cells.Veterinary world · 2022Article
- Glucose-Related Traits and Risk of Migraine-A Potential Mechanism and Treatment Consideration.Genes · 2022Review
- Male and female sex hormones in primary headaches.The journal of headache and pain · 2018Review
- The NRP1 migraine risk variant shows evidence of association with menstrual migraine.The journal of headache and pain · 2018Article
- Polygenic risk score: use in migraine research.The journal of headache and pain · 2018Review
- Development of an AmpliSeqFrontiers in pharmacology · 2018Article
- New evidence for involvement of ESR1 gene in susceptibility to Chinese migraine.Journal of neurology · 2017Article
- Contribution of polymorphisms in ESR1, ESR2, FSHR, CYP19A1, SHBG, and NRIP1 genes to migraine susceptibility in Turkish population.Journal of genetics · 2016Article
- Roads Less Traveled: Sexual Dimorphism and Mast Cell Contributions to Migraine Pathology.Frontiers in immunology · 2016Review
- Migraine genetics: current findings and future lines of research.Neurogenetics · 2015Article
- Progesterone receptor gene (PROGINS) polymorphism correlates with late onset of migraine.DNA and cell biology · 2015Article
- Sex and the migraine brain.Neurobiology of disease · 2014Review
- Endothelial Nitric Oxide Synthase and Angiotensin Converting Enzyme Gene Polymorphisms in Migraine Patients.Noro psikiyatri arsivi · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
Abstract
backgroundData on the association between sex hormone receptor polymorphisms and migraine are conflicting.
methodsWe performed a systematic review and meta-analysis on this topic searching for studies published until August 2009. For each study, we calculated odds ratios (ORs) and 95% confidence intervals (CIs) assuming additive, dominant, and recessive genetic models. We then calculated pooled ORs and 95% CIs. RESULTS AND
conclusionAmong the seven genes targeted, four variants were investigated in multiple studies. Effect estimates from an additive model suggest that the ESR-1 594 G>A (pooled OR 1.37; 95% CI 1.02-1.83) and ESR-1 325 C>G (pooled OR 1.16; 95% CI 1.03-1.32) variants are associated with any migraine. This pattern does not differ between migraine with and without aura. In contrast, the ESR-1 Pvu II C>T and PGR PROGINS insert polymorphism do not appear to be associated with migraine. Results were driven by studies among Caucasians and may differ in other ethnic groups.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.