SynthesisCephalalgia : an international journal of headache2010
5-HTTLPR polymorphism in the serotonin transporter gene and migraine: a systematic review and meta-analysis.
Synthesis in Cephalalgia : an international journal of headache, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Genetic variants in migraine: a field synopsis and systematic re-analysis of meta-analyses.The journal of headache and pain · 2020Pooled it
- STin2 VNTR polymorphism in the serotonin transporter gene and migraine: pooled and meta-analyses.The journal of headache and pain · 2010Pooled it
- Pharmacological mechanisms underlying neurovascular alterations related to resistant and refractory migraine: CGRP pathways and beyond.The journal of headache and pain · 2026Review
- Serotonin Transporter (5-Hydroxytryptamine Transporter, SERT, SLC6A4) and Sodium-dependent Reuptake Inhibitors as Modulators of Pain Behaviors and Analgesic Responses.The journal of pain · 2024Review
- Understanding the Biological Relationship between Migraine and Depression.Biomolecules · 2024Review
- Identification of genetic susceptibility for Chinese migraine with depression using machine learning.Frontiers in neurology · 2024Article
- Association analysis of serotonin transporter gene polymorphism among the South-Indian migraineurs.Current journal of neurology · 2023Article
- Correlation betweenTranslational pediatrics · 2022Article
- Review
- The exploration of mechanisms of comorbidity between migraine and depression.Journal of cellular and molecular medicine · 2019Review
- Impact of serotonin transporter gene on rTMS augmentation of SSRIs for obsessive compulsive disorder.Neuropsychiatric disease and treatment · 2019Article
- The New *G29A and G1222A ofFrontiers in molecular neuroscience · 2018Article
- Genetic and biochemical changes of the serotonergic system in migraine pathobiology.The journal of headache and pain · 2017Review
- Molecular factors in migraine.Oncotarget · 2016Review
- Folate Pathway Gene Methylenetetrahydrofolate Reductase C677T Polymorphism and Alzheimer Disease Risk in Asian Population.Indian journal of clinical biochemistry : IJCB · 2016Review
- Childhood Maltreatment in the Migraine Patient.Current treatment options in neurology · 2016Review
- Childhood Maltreatment and Headache Disorders.Current pain and headache reports · 2016Article
- Genome wide association study identifies variants in NBEA associated with migraine in bipolar disorder.Journal of affective disorders · 2015Article
- Bi-allelic and tri-allelic 5-HTTLPR polymorphisms and triptan non-response in cluster headache.The journal of headache and pain · 2014Article
- Serotonin, 5HT1 agonists, and migraine: new data, but old questions still not answered.Current opinion in supportive and palliative care · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
Abstract
BACKGROUND AND
methodsData on the association between the SLC6A4 5-HTTLPR polymorphism and migraine are conflicting. We performed a systematic review and meta-analysis among studies published up to September 2009. For each study with genotype information, we calculated odds ratios (OR) and 95% confidence intervals (CI) assuming additive, dominant, and recessive genetic models. We then calculated pooled ORs and 95% CIs.
resultsAmong the ten studies identified there was no overall association between the polymorphism and any migraine for Europeans or Asians. However, European women carrying the S allele had an increased risk for any migraine (dominant model: pooled OR=2.02; 95% CI 1.24-3.28). Results among Europeans further suggested an increased risk for migraine with aura among carriers of the S/S genotype (recessive model: pooled OR=1.41; 95% CI 0.83-2.40).
conclusionsWhile our results indicate no overall association between the SLC6A4 5-HTTLPR polymorphism and migraine among Europeans and Asians, gender and migraine aura status may have modifying roles among Europeans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.