ArticleThe Journal of pharmacology and experimental therapeutics2011
MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries.
Article in The Journal of pharmacology and experimental therapeutics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Melatonin alleviates diabetic-induced vascular dysfunction by modulating endothelin-1 receptors (ETA and ETB) reactivity in rat aortic rings.Acta diabetologica · 2026Article
- Cellular signalling of melatonin and its role in metabolic disorders.Molecular biology reports · 2025Review
- Melatonin and Vascular Function.Antioxidants (Basel, Switzerland) · 2024Review
- Melatonin MTAmerican journal of physiology. Lung cellular and molecular physiology · 2021Article
- Expression of Melatonin Receptor 1 in Rat Mesenteric Artery and Perivascular Adipose Tissue and Vasoactive Action of Melatonin.Cellular and molecular neurobiology · 2021Article
- Melatonin for the Management of Preeclampsia: A Review.Antioxidants (Basel, Switzerland) · 2021Review
- Apelin Does Not Impair Coronary Artery Relaxation Mediated by Nitric Oxide-Induced Activation of BKFrontiers in pharmacology · 2021Article
- Endogenous and Exogenous Melatonin Exposure Attenuates Hepatic MTAntioxidants (Basel, Switzerland) · 2019Article
- Activation of Large Conductance, Calcium-Activated Potassium Channels by Nitric Oxide Mediates Apelin-Induced Relaxation of Isolated Rat Coronary Arteries.The Journal of pharmacology and experimental therapeutics · 2018Article
- Stimulatory Effects of Melatonin on Porcine In Vitro Maturation Are Mediated by MT2 Receptor.International journal of molecular sciences · 2018Article
- Anti-Inflammatory Effects of Melatonin in Obesity and Hypertension.Current hypertension reports · 2018Review
- Antioxidant Melatonin: Potential Functions in Improving Cerebral Autoregulation After Subarachnoid Hemorrhage.Frontiers in physiology · 2018Review
- Modulation of mesenteric collecting lymphatic contractions by σAmerican journal of physiology. Heart and circulatory physiology · 2017Article
- Glucagon-like peptide-1 (GLP-1) receptor agonist prevents development of tolerance to anti-anxiety effect of ethanol and withdrawal-induced anxiety in rats.Metabolic brain disease · 2015Article
- Peripheral and central effects of melatonin on blood pressure regulation.International journal of molecular sciences · 2014Review
- Maternal nutrient restriction during pregnancy impairs an endothelium-derived hyperpolarizing factor-like pathway in sheep fetal coronary arteries.American journal of physiology. Heart and circulatory physiology · 2014Article
- Pulsed ultrasound enhances the delivery of nitric oxide from bubble liposomes to ex vivo porcine carotid tissue.International journal of nanomedicine · 2014Article
- Melatonin receptor agonist-induced reduction of SNP-released nitric oxide and cGMP production in isolated human non-pigmented ciliary epithelial cells.Experimental eye research · 2013Article
- Melatonin inhibits nitric oxide signaling by increasing PDE5 phosphorylation in coronary arteries.American journal of physiology. Heart and circulatory physiology · 2012Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Previous studies from our laboratory demonstrated that melatonin inhibits nitric oxide (NO)-induced relaxation in porcine coronary arteries. The present study was designed to further characterize the mechanisms underlying this inhibitory effect of melatonin. Western immunoblot studies identified the presence of melatonin type 2 (MT(2)) receptors, but not MT(1) or MT(3) receptors, in porcine coronary arteries. Immunohistochemical analysis revealed that MT(2) receptors colocalized with α-actin in the smooth muscle cell layer. In coronary arterial rings suspended in organ chambers for isometric tension recording, melatonin (10(-7) M) inhibited relaxations induced by the exogenous NO donor sodium nitroprusside (SNP; 10(-9) to 10(-5) M) and by the α(2)-adrenoceptor agonist 5-bromo-6-[2-imidazolin-2-yl-amino]-quinoxaline (UK14,304; 10(-9) to 10(-5) M), an endothelium-dependent vasodilator. The inhibitory effect of melatonin on SNP- and UK14,304-induced relaxations was abolished in the presence of the selective MT(2) receptor antagonists 4-phenyl-2-propionamidotetralin (4P-PDOT; 10(-7) M) and luzindole (10(-7) M). In contrast to melatonin, the selective MT(3) receptor agonist 5-methoxycarbonylamino-N-acetyltryptamine (5-MCA-NAT; 10(-7) M) had no effect on the concentration-response curves to either SNP or UK14,304. Melatonin (10(-7) M) had no effect on coronary artery relaxation induced by 8-bromoguanosine 3',5'-cyclic monophosphate, but it significantly attenuated the increase in intracellular cyclic GMP levels in response to SNP (10(-5) M). This effect of melatonin was abolished in the presence of 4P-PDOT (10(-7) M). Taken together, these data support the view that melatonin acts on MT(2) receptors in coronary vascular smooth muscle cells to inhibit NO-induced increases in cyclic GMP and coronary arterial relaxation, thus demonstrating a novel function for MT(2) receptors in the vasculature.
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