ArticleNucleic acids research2011
Protegen: a web-based protective antigen database and analysis system.
Article in Nucleic acids research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- COVID-19 Coronavirus Vaccine Design Using Reverse Vaccinology and Machine Learning.Frontiers in immunology · 2020Pooled it
- PU-GRAIL: residue-level graph learning for identifying protective bacterial antigens under positive-unlabeled supervision.Bioinformatics (Oxford, England) · 2026Article
- VO: The Vaccine Ontology.Scientific data · 2026Article
- Review
- Computational design of a novel multi-epitope vaccine candidate against group A rotavirus.Virology journal · 2026Article
- Computational identification of B- and T-cell epitopes: a unified task taxonomy and review of databases, datasets, predictive pipelines, and gaps.Frontiers in immunology · 2026Review
- Integrating protein language and geometric deep learning models for enhanced vaccine antigen prediction.Nature communications · 2025Article
- Legal questions of AI-generated immunological products for infectious diseases.Human vaccines & immunotherapeutics · 2025Review
- VO: The Vaccine Ontology.bioRxiv : the preprint server for biology · 2025Article
- Article
- VirusImmu: a novel ensemble machine learning approach for viral immunogenicity prediction.Briefings in functional genomics · 2025Article
- A descriptor-free machine learning framework to improve antigen discovery for bacterial pathogens.PloS one · 2025Article
- Systematic collection, annotation, and pattern analysis of viral vaccines in the VIOLIN vaccine knowledgebase.Frontiers in cellular and infection microbiology · 2025Article
- Advances of computational methods enhance the development of multi-epitope vaccines.Briefings in bioinformatics · 2024Review
- Enhancing Vaxign-DL for Vaccine Candidate Prediction with added ESM-Generated Features.bioRxiv : the preprint server for biology · 2024Article
- Integrating machine learning to advance epitope mapping.Frontiers in immunology · 2024Review
- Vaxign-DL: A Deep Learning-based Method for Vaccine Design and its Evaluation.bioRxiv : the preprint server for biology · 2023Article
- Vaxi-DL: An Artificial Intelligence-Enabled Platform for Vaccine Development.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Identification of missing hierarchical relations in the vaccine ontology using acquired term pairs.Journal of biomedical semantics · 2022Article
- COVID-19 vaccine design using reverse and structural vaccinology, ontology-based literature mining and machine learning.Briefings in bioinformatics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Protective antigens are specifically targeted by the acquired immune response of the host and are able to induce protection in the host against infectious and non-infectious diseases. Protective antigens play important roles in vaccine development, as biological markers for disease diagnosis, and for analysis of fundamental host immunity against diseases. Protegen is a web-based central database and analysis system that curates, stores and analyzes protective antigens. Basic antigen information and experimental evidence are curated from peer-reviewed articles. More detailed gene/protein information (e.g. DNA and protein sequences, and COG classification) are automatically extracted from existing databases using internally developed scripts. Bioinformatics programs are also applied to compute different antigen features, such as protein weight and pI, and subcellular localizations of bacterial proteins. Presently, 590 protective antigens have been curated against over 100 infectious diseases caused by pathogens and non-infectious diseases (including cancers and allergies). A user-friendly web query and visualization interface is developed for interactive protective antigen search. A customized BLAST sequence similarity search is also developed for analysis of new sequences provided by the users. To support data exchange, the information of protective antigens is stored in the Vaccine Ontology (VO) in OWL format and can also be exported to FASTA and Excel files. Protegen is publically available at http://www.violinet.org/protegen.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.