ArticleBiophysical journal2010
Cation charge dependence of the forces driving DNA assembly.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Phosphorylation of the protamine-like protein from baculovirus affects its DNA binding and virus propagation.Nucleic acids research · 2025Article
- Single-molecule measurements of double-stranded DNA condensation.Biophysical journal · 2025Review
- Influence of the Electrolyte Salt Concentration on DNA Detection with Graphene Transistors.Biosensors · 2021Article
- Structural Polymorphism of Single pDNA Condensates Elicited by Cationic Block Polyelectrolytes.Polymers · 2020Review
- Pressurized DNA state inside herpes capsids-A novel antiviral target.PLoS pathogens · 2020Article
- Specific effects of antitumor active norspermidine on the structure and function of DNA.Scientific reports · 2019Article
- A Comprehensive Biophysical Analysis of the Effect of DNA Binding Drugs on Protamine-induced DNA Condensation.Scientific reports · 2019Article
- The effects of IAM38 blocking or CD4 blocking on the binding of exogenous DNA in rabbit sperm.Molecular biology reports · 2019Article
- Extracellular Spermine Triggers a Rapid Intracellular Phosphatidic Acid Response in Arabidopsis, Involving PLDδ Activation and Stimulating Ion Flux.Frontiers in plant science · 2019Article
- Role of Disulfide Bonds on DNA Packaging Forces in Bull Sperm Chromatin.Biophysical journal · 2017Article
- Tuning DNA Condensation with Zwitterionic Polyamidoamine (zPAMAM) Dendrimers.Macromolecules · 2017Article
- Single Molecular Demonstration of Modulating Charge Inversion of DNA.Scientific reports · 2016Article
- Multivalent ion-mediated nucleic acid helix-helix interactions: RNA versus DNA.Nucleic acids research · 2015Article
- Why double-stranded RNA resists condensation.Nucleic acids research · 2014Article
- Helical structure determines different susceptibilities of dsDNA, dsRNA, and tsDNA to counterion-induced condensation.Biophysical journal · 2013Article
- A comparison of DNA compaction by arginine and lysine peptides: a physical basis for arginine rich protamines.Biochemistry · 2013Article
- Tunable soft structure in charged fluids confined by dielectric interfaces.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Role of amino acid insertions on intermolecular forces between arginine peptide condensed DNA helices: implications for protamine-DNA packaging in sperm.The Journal of biological chemistry · 2011Article
- Evidence for water structuring forces between surfaces.Current opinion in colloid & interface science · 2011Article
- Salt effects on condensed protamine-DNA assemblies: anion binding and weakening of attraction.The journal of physical chemistry. B · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Understanding the strength and specificity of interactions among biologically important macromolecules that control cellular functions requires quantitative knowledge of intermolecular forces. Controlled DNA condensation and assembly are particularly critical for biology, with separate repulsive and attractive intermolecular forces determining the extent of DNA compaction. How these forces depend on the charge of the condensing ion has not been determined, but such knowledge is fundamental for understanding the basis of DNA-DNA interactions. Here, we measure DNA force-distance curves for a homologous set of arginine peptides. All forces are well fit as the sum of two exponentials with 2.4- and 4.8-Å decay lengths. The shorter-decay-length force is always repulsive, with an amplitude that varies slightly with length or charge. The longer-decay-length force varies strongly with cation charge, changing from repulsion with Arg¹ to attraction with Arg². Force curves for a series of homologous polyamines and the heterogeneous protein protamine are quite similar, demonstrating the universality of these forces for DNA assembly. Repulsive amplitudes of the shorter-decay-length force are species-dependent but nearly independent of charge within each species. A striking observation was that the attractive force amplitudes for all samples collapse to a single curve, varying linearly with the inverse of the cation charge.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.