ArticleBiophysical journal2010
Shear-stabilized rolling behavior of E. coli examined with simulations.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Strategies to control cellular spatial organization in microphysiological systems.Microsystems & nanoengineering · 2026Review
- PreventingACS applied materials & interfaces · 2024Article
- Effect of Gravity on Bacterial Adhesion to Heterogeneous Surfaces.Pathogens (Basel, Switzerland) · 2023Article
- Extensible membrane nanotubules mediate attachment of Trypanosoma cruzi epimastigotes under flow.PloS one · 2023Article
- Mechanical Model for Catch-Bond-Mediated Cell Adhesion in Shear Flow.International journal of molecular sciences · 2020Article
- Growth of microorganisms in an interfacially driven space bioreactor analog.NPJ microgravity · 2020Article
- Targeting Dynamical Binding Processes in the Design of Non-Antibiotic Anti-Adhesives by Molecular Simulation-The Example of FimH.Molecules (Basel, Switzerland) · 2018Review
- A multiplexed magnetic tweezer with precision particle tracking and bi-directional force control.Journal of biological engineering · 2017Article
- Inactive conformation enhances binding function in physiological conditions.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Yielding elastic tethers stabilize robust cell adhesion.PLoS computational biology · 2014Article
- Allosteric coupling in the bacterial adhesive protein FimH.The Journal of biological chemistry · 2013Article
- The shaft of the type 1 fimbriae regulates an external force to match the FimH catch bond.Biophysical journal · 2013Article
- Article
- Impairment of the biomechanical compliance of P pili: a novel means of inhibiting uropathogenic bacterial infections?European biophysics journal : EBJ · 2012Article
- Multiscale Modeling of Functionalized Nanocarriers in Targeted Drug Delivery.Current nanoscience · 2011Article
- Multivalent binding of nanocarrier to endothelial cells under shear flow.Biophysical journal · 2011Article
- The bacterial fimbrial tip acts as a mechanical force sensor.PLoS biology · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Escherichia coli exhibit both shear-stabilized rolling and a transition to stationary adhesion while adhering in fluid flow. Understanding the mechanism by which this shear-enhanced adhesion occurs is an important step in understanding bacterial pathogenesis. In this work, simulations are used to investigate the relative contributions of fimbrial deformation and bond transitions to the rolling and stationary adhesion of E. coli. Each E. coli body is surrounded by many long, thin fimbriae terminating in a single FimH receptor that is capable of forming a catch bond with mannose. As simulated cells progress along a mannosylated surface under flow, the fimbriae bend and buckle as they interact with the surface, and FimH-mannose bonds form and break according to a two-state, allosteric catch-bond model. In simulations, shear-stabilized rolling resulted from an increase in the low-affinity bond number due to increased fimbrial deformation with shear. Catch-bond formation did not occur during cell rolling, but instead led to the transition to stationary adhesion. In contrast, in leukocyte and platelet systems, catch bonds appear to be involved in the stabilization of rolling, and integrin activation is required for stationary adhesion.
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