ArticleBiophysical journal2010
How long does it take to establish a morphogen gradient?
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Biological Systems Depend on Communication Over Distances: A Review of the Fundamental Mechanisms, Associated challenges, and the Potential Effect of the Constrained Disorder Principle.Acta biotheoretica · 2026Review
- Morphogen gradients are regulated by porous media characteristics of the developing tissue.Development (Cambridge, England) · 2025Article
- Receptor binding and tortuosity explain morphogen local-to-global diffusion coefficient transition.Biophysical journal · 2025Article
- Cellular diffusion processes in singularly perturbed domains.Journal of mathematical biology · 2024Review
- Size matters: tissue size as a marker for a transition between reaction-diffusion regimes in spatio-temporal distribution of morphogens.Royal Society open science · 2022Article
- Mathematical modeling of Erk activity waves in regenerating zebrafish scales.Biophysical journal · 2021Article
- Article
- Quantifying Temperature Compensation of Bicoid Gradients with a Fast T-Tunable Microfluidic Device.Biophysical journal · 2020Article
- Relaxation Times of Ligand-Receptor Complex Formation Control T Cell Activation.Biophysical journal · 2020Article
- Spatial modeling of the membrane-cytosolic interface in protein kinase signal transduction.PLoS computational biology · 2018Article
- Spatially Different Tissue-Scale Diffusivity Shapes ANGUSTIFOLIA3 Gradient in Growing Leaves.Biophysical journal · 2017Article
- Dendritic spine geometry can localize GTPase signaling in neurons.Molecular biology of the cell · 2015Article
- Spatiotemporal analysis of different mechanisms for interpreting morphogen gradients.Biophysical journal · 2015Article
- Mobility of signaling molecules: the key to deciphering plant organogenesis.Journal of plant research · 2015Review
- On the GFP-based analysis of dynamic concentration profiles.Biophysical journal · 2014Article
- Kinetics of receptor occupancy during morphogen gradient formation.The Journal of chemical physics · 2013Article
- Physical interpretation of mean local accumulation time of morphogen gradient formation.The Journal of chemical physics · 2011Article
- Measurement and perturbation of morphogen lifetime: effects on gradient shape.Biophysical journal · 2011Article
- Ordinary differential equation for local accumulation time.The Journal of chemical physics · 2011Article
- Formation of morphogen gradients: local accumulation time.Physical review. E, Statistical, nonlinear, and soft matter physics · 2011Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
Abstract
A morphogen gradient is defined as a concentration field of a molecule that acts as a dose-dependent regulator of cell differentiation. One of the key questions in studies of morphogen gradients is whether they reach steady states on timescales relevant for developmental patterning. We propose a systematic approach for addressing this question and illustrate it by analyzing several models that account for diffusion and degradation of locally produced chemical signals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.