ArticleZhongguo fei ai za zhi = Chinese journal of lung cancer2010
[Paclitaxel blocks immunologic escape through up-regulating TAP-1, TAP-2 and eliminatiing Treg cells in 3LL-bearing mice].
Article in Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND AND
objectiveUntil now, there are still some questions that chemotherapy could block cancer immunologic escape or not. The aim of this study is to explore the mechanism of paclitaxel in the blocking of immunologic escape in 3LL bearing mice.
methodsMHC class I components were detected by FACS antibodies TAP-1 and TAP-2 in 3LL group and 3LL pretreated with 5*10(-8) mmol/L paclitaxel. C57BL/6 mice were divided into 3 groups: tumor -bearing group, paclitaxel-treating group and tumor-free group. 3LL cells (0.3*10(6)) were injected via tail vein of mice. On day 8, paclitaxel (0.012 5 mg) was injected subcutaneously in the treatment group. On day 21, murine lung cells were suspended. With FACS triple staining, we analyzed expression of Treg in each group.
resultsThe expression of TAP-1 (5.68%+/-0.65%), TAP-2 (89.54%+/-4.8%) was remarkably higher in paclitaxel-pretreating 3LL group than that in 3LL bearing mice group with TAP-1 (1.93%+/-0.25%), TAP-2 (67.78%+/-5.08%), P=0.006, P=0.036 respectively. The expression of regulatory T cells (Treg) in tumor bearing mice was significantly higher (25.46%+/-2.23%) than that of in normal mice (12.46%+/-1.21%) (P < 0.001). Expression of Treg in paclitaxel treated mice was remarkably inhibited (17.53%+/-1.24%) compared with that in 3LL bearing mice group (P=0.004).
conclusionsPaclitaxel may block immunologic escape in the treatment of 3LL bearing mice partly through up-regulation TAP-1, TAP-2 and eliminating Treg cells.
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