ArticleJournal of clinical periodontology2010
Interferon-gamma promoter hypomethylation and increased expression in chronic periodontitis.
Article in Journal of clinical periodontology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 100 citations in OpenAlex.
- The Role of DNA Methylation and Histone Modification in Periodontal Disease: A Systematic Review.International journal of molecular sciences · 2020Pooled it
- Epigenetics and periodontics: A systematic review.Medicina oral, patologia oral y cirugia bucal · 2019Pooled it
- Interferon Crevicular Fluid Profile and Correlation with Periodontal Disease and Wound Healing: A Systemic Review of Recent Data.International journal of molecular sciences · 2018Pooled it
- Epigenetic regulation of inflammation in localized aggressive periodontitis.Clinical epigenetics · 2017Trial
- Salivary Microvesicle Methylome and Microbiome Profiles in Periodontitis: An Exploratory Study.Journal of clinical periodontology · 2026Article
- Matrix Stiffness Governs Fibroblasts' Regulation of Gingival Immune Homeostasis.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Genome-wide profiling of salivary promoter-region DNA methylation in periodontitis: the Tromsø Study.BMC medical genomics · 2026Article
- Matrix Stiffness Governs Fibroblast-Driven Immune Homeostasis in Gingival Tissues.bioRxiv : the preprint server for biology · 2025Article
- DNA Methylation of COX-2, IFN-γ, TNF-α, and LINE-1 in Clinically Stable Periodontal Tissues Following Periodontal Therapy.Clinical and experimental dental research · 2025Article
- The role of genome-wide DNA methylation and polymorphisms in periodontitis etiology: A narrative review.Biomolecules & biomedicine · 2025Review
- CRISPRJournal of oral microbiology · 2025Article
- Multi-omics integration to identify immune-associated biomarkers and potential therapeutics in periodontitis.Frontiers in medicine · 2025Article
- Can social adversity alter the epigenome, trigger oral disease, and affect future generations?Irish journal of medical science · 2024Review
- Methylome-wide analysis in systemic microbial-induced experimental periodontal disease in mice with different susceptibility.Frontiers in cellular and infection microbiology · 2024Article
- The Correlation Between IFNG Gene Methylation and Th1|Th2 Cell Balance in ROU and the Interventional Study of Jiaweidaochi Powder.Applied biochemistry and biotechnology · 2023Article
- DNA methylation changes underlie the long-term association between periodontitis and atherosclerotic cardiovascular disease.Frontiers in cardiovascular medicine · 2023Article
- Epigenetics in susceptibility, progression, and diagnosis of periodontitis.The Japanese dental science review · 2022Review
- Next-Generation Examination, Diagnosis, and Personalized Medicine in Periodontal Disease.Journal of personalized medicine · 2022Review
- The Relevance of DNA Methylation and Histone Modification in Periodontitis: A Scoping Review.Cells · 2022Article
- Exploring the Expression of Pro-Inflammatory and Hypoxia-Related MicroRNA-20a, MicroRNA-30e, and MicroRNA-93 in Periodontitis and Gingival Mesenchymal Stem Cells under Hypoxia.International journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
aimThe goal of this investigation was to determine whether epigenetic modifications in the IFNG promoter are associated with an increase of IFNG transcription in different stages of periodontal diseases. MATERIALS AND
methodsDNA was extracted from gingival biopsy samples collected from 47 total sites from 47 different subjects: 23 periodontally healthy sites, 12 experimentally induced gingivitis sites and 12 chronic periodontitis sites. Levels of DNA methylation within the IFNG promoter containing six CpG dinucleotides were determined using pyrosequencing technology. Interferon gamma mRNA expression was analysed by quantitative polymerase chain reactions using isolated RNA from part of the biological samples mentioned above.
resultsThe methylation level of all six analysed CpG sites within the IFNG promoter region in the periodontitis biopsies {52% [interquartile range, IQR (43.8%, 63%)]} was significantly lower than periodontally healthy samples {62% [IQR (51.3%, 74%)], p=0.007} and gingivitis biopsies {63% [IQR (55%, 74%)], p=0.02}. The transcriptional level of IFNG in periodontitis biopsies was 1.96-fold and significantly higher than tissues with periodontal health (p=0.04). Although the mRNA level from experimental gingivitis samples exhibited an 8.5-fold increase as compared with periodontally healthy samples, no significant methylation difference was observed in experimental gingivitis sample.
conclusionsA hypomethylation profile within IFNG promoter region is related to an increase of IFNG transcription present in the chronic periodontitis biopsies, while such an increase of IFNG in experimentally induced gingivitis seems independent of promoter methylation alteration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.