ReviewNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2011
Prescription of lipophilic statins to Alzheimer's disease patients: some controversies to consider.
Review in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Pravastatin But Not Simvastatin Improves Survival and Neurofunctional Outcome After Cardiac Arrest and Cardiopulmonary Resuscitation.JACC. Basic to translational science · 2017Article
- Association of Long-Term Atorvastatin with Escalated Stroke-Induced Neuroinflammation in Rats.Journal of molecular neuroscience : MN · 2017Article
- Protective Effect of DHT on Apoptosis Induced by U18666A via PI3K/Akt Signaling Pathway in C6 Glial Cell Lines.Cellular and molecular neurobiology · 2016Article
- Effect of cholesterol reduction on receptor signaling in neurons.The Journal of biological chemistry · 2015Article
- Long-term atorvastatin treatment leads to alterations in behavior, cognition, and hippocampal biochemistry.Behavioural brain research · 2014Article
- Nonlinear longitudinal trajectories of cholesterol and neuropsychological function.Neuropsychology · 2014Article
- Problems and possible solutions for therapy with statins.The International journal of angiology : official publication of the International College of Angiology, Inc · 2013Review
- Pore formation in lipid bilayer membranes made of phosphatidylcholine and cholesterol followed by means of constant current.Cell biochemistry and biophysics · 2013Article
- Regulation of cerebral cholesterol metabolism in Alzheimer disease.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2012Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD) is the most common disorder causing cognitive decline in old age. It is a progressive and irreversible neuropathology with a diagnosis often missed or delayed. Cholesterol represents an important determinant of the physical state of biological membranes and in AD brains, specific changes in its membrane-ordering and Raft-organizing effects take place. A recent publication shows downregulation of Seladin-1 (selective Alzheimer's disease indicator, also called DHCR24), which catalyzes the last step of cholesterol biosynthesis in affected neurons in AD. Postmortem analysis of AD brains revealed a loss in membrane cholesterol content and this finding makes the therapeutical use of statins (especially the lipophilic ones) quite a lot controversial. Some clinical studies suggest that risk of Alzheimer's disease is substantially reduced in users of statins; however, because these studies are not randomized trials, they provide insufficient evidence to recommend statin family therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.