ArticleDevelopment genes and evolution2010
Expression of Hox genes during the larval development of the snail, Gibbula varia (L.)-further evidence of non-colinearity in molluscs.
Article in Development genes and evolution, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 57 citations in OpenAlex.
- Anterior-posterior patterning in the chaetognath Spadella cephaloptera informs bilaterian nervous system and tail evolution.Communications biology · 2025Article
- Evolution of Duplicated Hox Gene Clusters in Land Snails and Slugs.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2025Article
- Octopod Hox genes and cephalopod plesiomorphies.Scientific reports · 2023Article
- Evolutionary conservation and divergence of the transcriptional regulation of bivalve shell secretion across life-history stages.Royal Society open science · 2022Article
- The genome of the venomous snail Lautoconus ventricosus sheds light on the origin of conotoxin diversity.GigaScience · 2021Article
- Non-collinear Hox gene expression in bivalves and the evolution of morphological novelties in mollusks.Scientific reports · 2021Article
- Homeotic Genes: Clustering, Modularity, and Diversity.Frontiers in cell and developmental biology · 2021Review
- Early shell field morphogenesis of a patellogastropod mollusk predominantly relies on cell movement and F-actin dynamics.BMC developmental biology · 2020Article
- Dorsoventral decoupling of Hox gene expression underpins the diversification of molluscs.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Hox gene expression during development of the phoronidEvoDevo · 2020Article
- The evolution of molluscs.Biological reviews of the Cambridge Philosophical Society · 2019Article
- Connectivity Among Populations of the Top ShellFrontiers in genetics · 2019Article
- Article
- Staggered Hox expression is more widespread among molluscs than previously appreciated.Proceedings. Biological sciences · 2018Article
- Clustered brachiopod Hox genes are not expressed collinearly and are associated with lophotrochozoan novelties.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Comparative transcriptomics enlarges the toolkit of known developmental genes in mollusks.BMC genomics · 2016Article
- An Overview ofJournal of developmental biology · 2016Review
- Hox and ParaHox gene expression in early body plan patterning of polyplacophoran mollusks.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2016Article
- Sea shell diversity and rapidly evolving secretomes: insights into the evolution of biomineralization.Frontiers in zoology · 2016Review
- Unexpected co-linearity of Hox gene expression in an aculiferan mollusk.BMC evolutionary biology · 2015Article
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Hox transcription factors, a subfamily of homeobox genes, are expressed in distinct, often overlapping domains along the anterior-posterior body axis of animal embryos. Here, we report the sequence and expression pattern of Hox2, Hox3, Hox4, Hox5, Lox5, Hox7, Lox4, and Lox2 in different larval stages during the encapsulated development of the marine gastropod Gibbula varia. Our results show that all Gva-Hox genes are expressed in ectoderm-derived cells. Hox2, Hox3, Hox4, Hox5, and Hox7 are expressed in overlapping patterns in the pedal, pleural, oesophageal, and visceral ganglia, supporting the ancestral role of Hox genes in the neurogenesis processes in bilaterians. Gva-Hox1, Gva-Post2, and Gva-Post1 genes are involved in shell morphogenesis and have apparently lost their role in neurogangliogenesis. Lox5, Lox4, and Lox2 are expressed in different cells of the apical organ during the earlier larval stage (trochophore) and the cerebral ganglia during later larval stages (veliger). These results support the hypothesis that apical organ neurosensory cells contribute to the formation of cerebral ganglia commissures during metamorphosis. Gva-Hox7 and Gva-Lox4 are additionally expressed in the prototroch of the trochophore and in the velar area of the veliger larvae. This contradicts with the expression of these genes in the annelids, where most of Hox genes are expressed in the posttrochal area and are involved in segmental determination. Therefore, expression of Hox genes may serve as an example of co-option and plasticity of gene function during evolution of gastropods.
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