ArticlePloS one2010
Molecular mechanisms of persistence of mutualistic bacteria Photorhabdus in the entomopathogenic nematode host.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- RNA-Sequencing of Heterorhabditis nematodes to identify factors involved in symbiosis with Photorhabdus bacteria.BMC genomics · 2022Article
- Review
- Novel metabolic interactions and environmental conditions mediate the boreal peatmoss-cyanobacteria mutualism.The ISME journal · 2022Article
- Review
- Molecular Regulators of Entomopathogenic Nematode-Bacterial Symbiosis.Results and problems in cell differentiation · 2020Review
- Comparative Analysis of Xenorhabdus koppenhoeferi Gene Expression during Symbiotic Persistence in the Host Nematode.PloS one · 2016Article
- Purine biosynthesis-deficient Burkholderia mutants are incapable of symbiotic accommodation in the stinkbug.The ISME journal · 2014Article
- Culture-independent investigation of the microbiome associated with the nematode Acrobeloides maximus.PloS one · 2013Article
- Nematode-bacterium symbioses--cooperation and conflict revealed in the "omics" age.The Biological bulletin · 2012Review
- Selective Capture of Transcribed Sequences: A Promising Approach for Investigating Bacterium-Insect Interactions.Insects · 2012Review
- Genetic and proteomic characterization of rpoB mutations and their effect on nematicidal activity in Photorhabdus luminescens LN2.PloS one · 2012Article
- The entomopathogenic bacterial endosymbionts Xenorhabdus and Photorhabdus: convergent lifestyles from divergent genomes.PloS one · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Symbioses between microbes and animals are ubiquitous, yet little is known about the intricate mechanisms maintaining such associations. In an emerging mutualistic model system, insect-pathogenic bacteria Photorhabdus and their insect-parasitic nematode partner Heterorhabditis, we found that the bacteria undergo major transcriptional reshaping in the nematode intestine. Besides general starvation mechanisms, the bacteria induce cellular acidification to slow down growth, switch to pentose phosphate pathway to overcome oxidative stress and nutrition limitation, and shed motility but develop biofilm to persist in the nematode intestine until being released into the insect hemolymph. These findings demonstrate how the symbiotic bacteria reduce their nutritional dependence on the enduring nematode partner to ensure successful transmission of the couple to the next insect host.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.